Mal-PEG8-Val-Ala-Exatecan
Based on 1 Customer Validation
Mal-PEG8-Val-Ala-Exatecan (Compound 1033) is a Drug-Linker Conjugates for ADC, which is composed of Exatecan (HY-13631) and a linker. Mal-PEG8-Val-Ala-Exatecan can be used for ADC synthesis.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.55%
- CAS No.: 3025787-70-3
- 화학식: C58H78FN7O18
- 분자량:1180.27
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보관:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
All Drug-Linker Conjugates for ADC Isoforms
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Biological Activity
Exatecan is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL), and it can be used in cancer research.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3025787-70-3
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Appearance Solid
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분자량 1180.27
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화학식 C58H78FN7O18
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Color Light yellow to yellow
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SMILES
O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C5C6=C(CC[C@@H]5NC([C@H](C)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCN7C(C=CC7=O)=O)=O)=O)=O)=O)C(C)=C(F)C=C6N=C4C3=C2)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
용액&용해도
DMSO : 100 mg/mL (84.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8473 mL | 4.2363 mL | 8.4726 mL | 21.1816 mL |
| 5 mM | 0.1695 mL | 0.8473 mL | 1.6945 mL | 4.2363 mL | |
| 10 mM | 0.0847 mL | 0.4236 mL | 0.8473 mL | 2.1182 mL | |
| 15 mM | 0.0565 mL | 0.2824 mL | 0.5648 mL | 1.4121 mL | |
| 20 mM | 0.0424 mL | 0.2118 mL | 0.4236 mL | 1.0591 mL | |
| 25 mM | 0.0339 mL | 0.1695 mL | 0.3389 mL | 0.8473 mL | |
| 30 mM | 0.0282 mL | 0.1412 mL | 0.2824 mL | 0.7061 mL | |
| 40 mM | 0.0212 mL | 0.1059 mL | 0.2118 mL | 0.5295 mL | |
| 50 mM | 0.0169 mL | 0.0847 mL | 0.1695 mL | 0.4236 mL | |
| 60 mM | 0.0141 mL | 0.0706 mL | 0.1412 mL | 0.3530 mL | |
| 80 mM | 0.0106 mL | 0.0530 mL | 0.1059 mL | 0.2648 mL |
Mal-PEG8-Val-Ala-Exatecan Related Classifications
HY-176766 Related Classifications
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