Mt KARI-IN-2
Mt KARI-IN-2 (compound 5b) is a potent Mycobacterium tuberculosis ketol-acid reductoisomerase (Mtb KARI) inhibitor with a Ki value of 2.02 μM. Mt KARI-IN-2 has inhibitory activity against Mtb H37Rv (MIC = 0.78 μM) and low cytotoxicity (HEK IC50 > 86 μg/mL).
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- CAS No.: 2413974-52-2
- 화학식: C14H11N5O4S2
- 분자량:377.40
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Ki: 2.02 μM (Mtb KARI)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
86 μM
Compound: 5b
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Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 48 hrs by MTT assay
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[PMID: 32171154] |
Chemical Information
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CAS No. 2413974-52-2
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분자량 377.40
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화학식 C14H11N5O4S2
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SMILES
COC1=CC=C(C=C1)NC(NC2=NN=C(S2)C3=CC=C(O3)[N+]([O-])=O)=S
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mt KARI-IN-2 Related Classifications
HY-146299 Related Classifications
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