NRX-103094
Based on 1 Customer Validation
NRX-103094 is a potent enhancer of the interaction between β-catenin, and its cognate E3 ligase, SCFβ-TrCP. NRX-103094 enhances the binding of pSer33/Ser37 β-catenin peptide for β-TrCP with an EC50 of 62 nM and a Kd of 0.6 nM.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- Purity: 99.89%
- CAS No.: 2763260-36-0
- 화학식: C20H11Cl2F3N2O4S
- 분자량:503.28
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
EC50: 62 nM (β-catenin:β-TrCP Interaction)[1]
Kd: 0.6 nM (β-catenin:β-TrCP Interaction)[1]
NRX-103094 shows high potency with pSer33/Ser37 β-catenin peptide (EC50 of 457 nM). NRX-103094 potentiates the ubiquitylation of pSer33/S37A β-catenin peptide to levels greater than wild-type pSer33/pSer37 levels at 250 nM[1].
NRX-103094 enhances the S33E/S37A phosphomimetic peptide binding affinity for β-TrCP from >5 μM in the absence of compound to 22 nM in the presence of 40 μM compound. In the presence of 20 μM NRX-103094, robust time-dependent ubiquitylation of S33E/S37A β-catenin peptide is observed. Likewise, the full-length S33E/S37A β-catenin protein is strongly ubiquitylated in the presence of 20 μM NRX-103094, with the ubiquitylation levels approaching that of WT full-length β-catenin protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2763260-36-0
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Appearance Solid
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분자량 503.28
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화학식 C20H11Cl2F3N2O4S
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Color White to off-white
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SMILES
OC(C1=CC=CC(NC(C2=C(C=C(NC2=O)C(F)(F)F)SC3=C(C=CC=C3Cl)Cl)=O)=C1)=O
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 50 mg/mL (99.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9870 mL | 9.9348 mL | 19.8697 mL | 49.6741 mL |
| 5 mM | 0.3974 mL | 1.9870 mL | 3.9739 mL | 9.9348 mL | |
| 10 mM | 0.1987 mL | 0.9935 mL | 1.9870 mL | 4.9674 mL | |
| 15 mM | 0.1325 mL | 0.6623 mL | 1.3246 mL | 3.3116 mL | |
| 20 mM | 0.0993 mL | 0.4967 mL | 0.9935 mL | 2.4837 mL | |
| 25 mM | 0.0795 mL | 0.3974 mL | 0.7948 mL | 1.9870 mL | |
| 30 mM | 0.0662 mL | 0.3312 mL | 0.6623 mL | 1.6558 mL | |
| 40 mM | 0.0497 mL | 0.2484 mL | 0.4967 mL | 1.2419 mL | |
| 50 mM | 0.0397 mL | 0.1987 mL | 0.3974 mL | 0.9935 mL | |
| 60 mM | 0.0331 mL | 0.1656 mL | 0.3312 mL | 0.8279 mL | |
| 80 mM | 0.0248 mL | 0.1242 mL | 0.2484 mL | 0.6209 mL |
NRX-103094 Related Classifications
HY-141449 Related Classifications
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