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Cat. No.: HY-186105

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P7C3-S243

P7C3-S243 is a brain-penetrant P7C3 class of neuroprotective agent. P7C3-S243 augments synthesis of nicotinamide adenine dinucleotide through activation of the metabolic enzyme nicotinamide phosphoribosyltransferase. P7C3-S243 shows potent neuroprotective efficacy in parkinson’s disease mice models. P7C3-S243 can be used for the research of parkinson’s disease.

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CAS No.: 1421622-85-6
화학식: C₂₁H₁₈Br₂FN₃O
분자량:507.19

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

P7C3-S243 Chemical Structure

CAS No.: 1421622-85-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

제품 설명

In Vivo

P7C3-S243 (10 mg/kg/day; i.p.; pre-administration for 3 days before induction and continuous administration for 7 days after induction) protects against 6-OHDA-induced dopaminergic neuron death, preserves striatal dopamine and metabolite levels, and restores normal motor behavior in a rat model of Parkinson's disease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Long Evans (adult male, 250-300 g, unilateral stereotactic injection of 6-OHDA into right median forebrain bundle)^[1]
Dosage:

10 mg/kg/day
Administration:

intraperitoneal injection; daily; 7 days (with 3 days of pretreatment before 6-OHDA injection)
Result:

Restored rearing ability, spontaneous locomotor activity, and reduced amphetamine-induced ipsiversive circling.
Increased survival of tyrosine hydroxylase-positive neurons in the ipsilateral substantia nigra pars.
Preserved tyrosine hydroxylase and NeuN colocalization in substantia nigra pars compacta neurons, with survival levels approximating sham-injured rats.
Significantly restored levels of striatal dopamine, DOPAC, and homovanillic acid toward normal sham-injured levels; no effect on striatal serotonin levels.

Chemical Information

CAS No. 1421622-85-6
분자량 507.19
화학식 C₂₁H₁₈Br₂FN₃O
SMILES

FC(CN1C2=CC=C(C=C2C3=C1C=CC(Br)=C3)Br)CNC4=NC(OC)=CC=C4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. De Jesús-Cortés H, Miller A D, Britt J K, et al. Protective efficacy of P7C3-S243 in the 6-hydroxydopamine model of Parkinson's disease[J]. NPJ Parkinson's disease, 2015, 1(1): 1-6. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

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100 mg

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