Penetratin-Cys
Penetratin-Cys is a cell-penetrating peptide derived from Antennapedia Peptide (HY-P0307) via C-terminal cysteine modification. Penetratin-Cys acts as a cytotoxin and reduces the viability of differentiated neuronal cells. Penetratin-Cys localizes to the perinuclear region and binds to the Golgi apparatus. Penetratin-Cys can be used in research related to neurological disorders.
연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.
- CAS No.: 393511-85-8
- 화학식: C107H173N35O21S2
- 분자량:2349.87
-
보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- 순도&문서
- References
-
Help & FAQs
Biological Activity
Penetratin-Cys dimer (50-400 μg/mL; 24 h) exhibits strong cytotoxicity against differentiated SH-SY5Y cells at the concentration of 400 μg/mL, and shows moderate cytotoxicity against HeLa cells and undifferentiated SH-SY5Y cells across the tested concentration range[1].
Penetratin-Cys dimer (7 μM/liter; 2-24 h) efficiently enters HeLa cells and localizes to the perinuclear region associated with the Golgi apparatus after 24 h of incubation[1].
Penetratin-Cys dimer exhibits weak antibacterial activity against E. coli, M. luteus, and S. aureus, with their MIC values ranging from 8 μmol/liter to >32 μmol/liter depending on the strain[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HeLa, undifferentiated SH-SY5Y, differentiated SH-SY5Y
-
Concentration:50 μg/mL, 100 μg/mL, 200 μg/mL, 400 μg/mL
-
Incubation Time:24 h
-
Result:Reduced HeLa cell viability to levels below 60% at 400 μg/mL.
Reduced undifferentiated SH-SY5Y cell viability to levels similar to penetratin-PrAMP constructs at 200 μg/mL.
Reduced differentiated SH-SY5Y cell viability to ~30% at 400 μg/mL.
-
Cell Line:HeLa
-
Concentration:7 μM/liter
-
Incubation Time:2 h, 24 h
-
Result:Entered HeLa cells and aligned perinuclear in small distinct spots after 2 h.
Formed a dense cloud associated with the Golgi apparatus after 24 h.
Chemical Information
-
CAS No. 393511-85-8
-
분자량 2349.87
-
화학식 C107H173N35O21S2
-
Sequence
Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Cys
-
Sequence Shortening
RQIKIWFQNRRMKWKKC
-
선적
Room temperature in continental US; may vary elsewhere.
-
보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Penetratin-Cys Related Classifications
HY-P0307B Related Classifications
Powered by Bioz