Peniditerpenoid A
Peniditerpenoid A is a di-seco-indole diterpenoid. Peniditerpenoid A decreases the expression of p-IkBαby RANKL induced. Peniditerpenoid A inhibits RANKL induced osteoclast differentiation. Peniditerpenoid A has the potential for the research of osteoporosis.
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- CAS No.: 2982771-74-2
- 화학식: C27H33NO7
- 분자량:483.55
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
11 μM
Compound: 1
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Antiinflammatory activity against mouse RAW264.7 cells stably transfected with luciferase reporter gene assessed as inhibition of LPS-induced NF-kB activation preincubated for 30 min followed by LPS stimulation for 8 hrs by luciferase based assay
Antiinflammatory activity against mouse RAW264.7 cells stably transfected with luciferase reporter gene assessed as inhibition of LPS-induced NF-kB activation preincubated for 30 min followed by LPS stimulation for 8 hrs by luciferase based assay
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[PMID: 38634860] |
Peniditerpenoid A (compound 1) (5, 10, 20 µM) inhibits RANKL induced osteoclast differentiation in a dose-dependent manner[1].
Peniditerpenoid A (5, 10, 20 µM) decreases the expression of p-IkBα in RAW264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:5, 10, 20 µM
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Incubation Time:4h+RANKL (100 ng/mL) for 30 min or 24 h
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Result:Reduced IκBα phosphorylation, elevated cytoplasmic p65 and inhibited p65 nuclear translocation.
Chemical Information
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CAS No. 2982771-74-2
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분자량 483.55
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화학식 C27H33NO7
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SMILES
O=C(C[C@](CC[C@]12O)([C@@](C(O)=O)(C)[C@@]1(C)CC[C@]3(OC4(C)C)C2=CC([C@@H]4O3)=O)[H])C5=CC=CC=C5N
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Structure Classification
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Initial Source
Mangrove Sediment-Derived Penicillium sp.
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Peniditerpenoid A Related Classifications
HY-N12836 Related Classifications
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