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Cat. No.: HY-P11266

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Phakellistatin 13

Phakellistatin 13 is a natural cycloheptapeptide with anti-tumor activity. Phakellistatin 13 exhibits a potent inhibitory effect on liver cancer cells BEL-7404 (ED₅₀0 < 0.01 μg/mL). Phakellistatin 13 can be used for research on liver cancer.

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CAS No.: 493012-52-5
화학식: C₄₂H₅₄N₈O₈
분자량:798.93

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Phakellistatin 13 Chemical Structure

CAS No.: 493012-52-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
4T1	IC₅₀	26.8 μM Compound: Phakellistatin 13	Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse 4T1 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
Bel-7402	ED₅₀	<0.01 μg/mL Compound: 3	Cytotoxicity against human Bel-7402 Cytotoxicity against human Bel-7402	[PMID: 17190452]
HeLa	IC₅₀	28.05 μM Compound: Phakellistatin 13	Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HeLa cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
HepG2	IC₅₀	13.1 μM Compound: Phakellistatin 13	Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human HepG2 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
L929	IC₅₀	>100 μM Compound: Phakellistatin 13	Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay Antiproliferative activity against mouse L929 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]
MDA-MB-231	IC₅₀	20.5 μM Compound: Phakellistatin 13	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by MTT assay	[PMID: 38990190]

Chemical Information

CAS No. 493012-52-5
분자량 798.93
화학식 C₄₂H₅₄N₈O₈
Sequence

cyclo(Pro-Phe-Gly-Pro-Thr-Leu-Trp)
Sequence Shortening

cyclo(PFGPTLW)
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li T, et al. Exploring the Potential of Cyclic Peptidyl Antitumor Agents Derived from Natural Macrocyclic Peptide Phakellistatin 13. J Med Chem. 2024 Jul 25;67(14):11789-11813. [Content Brief]

Calculators

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Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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