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Cat. No.: HY-183198

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PIM-IN-5

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia.

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CAS No.: 2139294-71-4
화학식: C₁₆H₁₈Cl₂N₄O
분자량:353.25

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

PIM-IN-5 Chemical Structure

CAS No.: 2139294-71-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

PIM-IN-5 is a PIM kinase inhibitor. PIM-IN-5 can be used for the research of acute myeloid leukemia^[1].

All Pim Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
KG-1	IC₅₀	62 nM Compound: (S)-11	Antiproliferative activity against human KG1 cells Antiproliferative activity against human KG1 cells	[PMID: 28927793]

In Vitro

PIM-IN-5 (Compound 1) inhibits KG1 cell viability with an EC₅₀ of 43 nM^[1].
PIM-IN-5 inhibits pS6 in KG1 cells with an EC₅₀ of 62 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2139294-71-4
분자량 353.25
화학식 C₁₆H₁₈Cl₂N₄O
SMILES

ClC1=C(C2CC2)N([C@H]3CCCNC3)C4=NC(C(N)=O)=CC(Cl)=C41
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Barberis C, et al. Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett. 2019;29(3):491-495. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
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PIM-IN-5

All Pim Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

PIM-IN-5 Related Classifications

HY-183198 Related Classifications