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Cat. No.: HY-P11831

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RD-pepcan-11

RD-pepcan-11 is a CB1 receptor agonist. RD-pepcan-11 increases the relative phosphorylation level of ERK1/2. RD-pepcan-11 mediates analgesic effects through interaction with CB1 receptors in a carrageenan-induced mouse inflammatory pain model. RD-pepcan-11 can be used in studies related to inflammatory pain.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

화학식: C₅₂H₈₆N₁₆O₁₆
분자량:1191.34

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

맞춤형 펩타이드 합성

RD-pepcan-11 Chemical Structure

사이즈

가격

재고

수량

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

CB1

All Cannabinoid Receptor Isoforms :

In Vitro

RD-pepcan-11 (300 μM; 10 min) acts as a CB1 receptor agonist in CB1-overexpressing CHO-K1 cells, with increased agonist activity observed at a concentration of 300 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

CB1 receptor-overexpressing CHO-K1 cells
Concentration:

300 μM
Incubation Time:

10 min
Result:

Exhibited higher agonist activity toward the CB1 receptor, as indicated by increased ERK1/2 phosphorylation relative to control conditions.

In Vivo

RD-pepcan-11 (3.25-30 nM/mouse; administered intratracheally) exerts a dose-dependent, CB1 receptor-mediated analgesic effect in a carrageenan-induced mouse model of inflammatory pain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Kunming mice (male, 6-8 weeks old, 25 g)^[1]
Dosage:

3.25, 7.5, 15, 30 nM/mouse
Administration:

i.t.
Result:

Produced significantly higher AUC values than normal saline control at 7.5, 15, and 30 nM per mouse.
Demonstrated peak antinociceptive effect and AUC value slightly exceeding positive control WIN55212-2 (7.5 nM per mouse) at 30 nM per mouse.
Had antinociceptive effects almost completely blocked by CB1 receptor antagonist AM251 pretreatment.
Showed no significant attenuation of antinociceptive effects by CB2 receptor antagonist AM630 pretreatment.

Chemical Information

분자량 1191.34
화학식 C₅₂H₈₆N₁₆O₁₆
Sequence

Ser-Ala-Leu-Ser-Asp-Leu-His-Ala-His-Lys-Leu
Sequence Shortening

SALSDLHAHKL
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Man H, et al. Multimodal profiling of Pepcan-CB1 receptor structure-activity relationships: integrating molecular dynamics simulations, biological profiling, and the deep learning model MuMoPepcan. Bioorg Chem. 2025;165:109027. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

RD-pepcan-11

All Cannabinoid Receptor Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

RD-pepcan-11 Related Classifications

HY-P11831 Related Classifications