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Cat. No.: HY-130126

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Sucunamostat hydrate

(Synonyms: SCO-792)

Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC₅₀s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.

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화학식: C₂₂H₂₂N₄O₈.xH₂O

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Sucunamostat hydrate Chemical Structure

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vivo
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target

IC₅₀: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)^[1]

In Vivo

Sucunamostat hydrate (10 and 30 mg/kg; PO, single dosage) effectively and dose-dependently inhibits plasma branched-chain amino acids (BCAA) elevations induced by oral protein dosing in rats^[1].

Pharmacokinetic Parameters of Sucunamostat hydrate in male Sprague-Dawley rats^[1].

	PO (10 mg/kg)	IV (2 mg/kg)
C_max (ng/mL)	6.60 ± 1.36	564 ± 58
T_max (h)	1.7 ± 0.6
AUC_0-24 (ng/mL·h)	54.1 ± 7.5	303 ± 23
AUC_inf (ng/mL·h)	49.8 ± 5.4	304 ± 30
Vd_SS (mL/kg)		1290 ± 299
CL_p (mL/min/kg)		663 ± 66
bioavailability (%)	0.4

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

화학식 C₂₂H₂₂N₄O₈.xH₂O
SMILES

O=C(O)C[C@@H](C(O)=O)NC(C[C@@H]1COC2=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=CC=C12)=O.[x].O
Synonyms

SCO-792
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sasaki M, et al. Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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