Sucunamostat hydrochloride
Based on 1 Customer Validation
Sucunamostat (SCO-792) hydrochloride is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrochloride can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.
For research use only. We do not sell to patients.
- Purity: 98.14%
- Formula: C22H23ClN4O8
- Molecular Weight:506.89
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Kinase Inhibitor Library
HY-L009
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Metabolism/Protease Compound Library
HY-L012
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Orally Active Compound Library
HY-L061
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Metabolic Enzyme Compound Library
HY-L146
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
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Posttranslational Modification Library
HY-L226
Biological Activity
IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)[1]
Pharmacokinetic Parameters of Sucunamostat hydrochloride in male Sprague-Dawley rats[1]
| PO (10 mg/kg) | IV (2 mg/kg) | |
| Cmax (ng/mL) | 6.60 ± 1.36 | 564 ± 58 |
| Tmax (h) | 1.7 ± 0.6 | |
| AUC0-24 (ng/mL·h) | 54.1 ± 7.5 | 303 ± 23 |
| AUCinf (ng/mL·h) | 49.8 ± 5.4 | 304 ± 30 |
| VdSS (mL/kg) | 1290 ± 299 | |
| CLp (mL/min/kg) | 663 ± 66 | |
| bioavailability (%) | 0.4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 506.89
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Formula C22H23ClN4O8
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Color White to off-white
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SMILES
[H]Cl.OC(C[C@@H](C(O)=O)NC(C[C@H]1C2=CC=C(OC(C3=CC=C(C=C3)NC(N)=N)=O)C=C2OC1)=O)=O
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Synonyms
SCO-792 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 125 mg/mL (246.60 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9728 mL | 9.8641 mL | 19.7281 mL | 49.3204 mL |
| 5 mM | 0.3946 mL | 1.9728 mL | 3.9456 mL | 9.8641 mL | |
| 10 mM | 0.1973 mL | 0.9864 mL | 1.9728 mL | 4.9320 mL | |
| 15 mM | 0.1315 mL | 0.6576 mL | 1.3152 mL | 3.2880 mL | |
| 20 mM | 0.0986 mL | 0.4932 mL | 0.9864 mL | 2.4660 mL | |
| 25 mM | 0.0789 mL | 0.3946 mL | 0.7891 mL | 1.9728 mL | |
| 30 mM | 0.0658 mL | 0.3288 mL | 0.6576 mL | 1.6440 mL | |
| 40 mM | 0.0493 mL | 0.2466 mL | 0.4932 mL | 1.2330 mL | |
| 50 mM | 0.0395 mL | 0.1973 mL | 0.3946 mL | 0.9864 mL | |
| 60 mM | 0.0329 mL | 0.1644 mL | 0.3288 mL | 0.8220 mL | |
| 80 mM | 0.0247 mL | 0.1233 mL | 0.2466 mL | 0.6165 mL | |
| 100 mM | 0.0197 mL | 0.0986 mL | 0.1973 mL | 0.4932 mL |
Sucunamostat hydrochloride Related Classifications
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