Sucunamostat hydrate
Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.
For research use only. We do not sell to patients.
- Formula: C22H22N4O8.xH2O
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)[1]
Pharmacokinetic Parameters of Sucunamostat hydrate in male Sprague-Dawley rats[1].
| PO (10 mg/kg) | IV (2 mg/kg) | |
| Cmax (ng/mL) | 6.60 ± 1.36 | 564 ± 58 |
| Tmax (h) | 1.7 ± 0.6 | |
| AUC0-24 (ng/mL·h) | 54.1 ± 7.5 | 303 ± 23 |
| AUCinf (ng/mL·h) | 49.8 ± 5.4 | 304 ± 30 |
| VdSS (mL/kg) | 1290 ± 299 | |
| CLp (mL/min/kg) | 663 ± 66 | |
| bioavailability (%) | 0.4 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Formula C22H22N4O8.xH2O
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SMILES
O=C(O)C[C@@H](C(O)=O)NC(C[C@@H]1COC2=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=CC=C12)=O.[x].O
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Synonyms
SCO-792
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sucunamostat hydrate Related Classifications
HY-130126 Related Classifications
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