2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. Laniquidar

Laniquidar is a non-competitive P-gp inhibitor with an IC50 of 0.51 μM. Laniquidar binds to the P-gp transporter with high affinity and exhibits low activity as a substrate. Laniquidar is applicable to epilepsy-related research.

For research use only. We do not sell to patients.

Laniquidar

Laniquidar Chemical Structure

CAS No. : 197509-46-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
1 mg In-stock
5 mg In-stock
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Laniquidar Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Laniquidar is a non-competitive P-gp inhibitor with an IC50 of 0.51 μM. Laniquidar binds to the P-gp transporter with high affinity and exhibits low activity as a substrate. Laniquidar is applicable to epilepsy-related research[1].

IC50 & Target

IC50: 0.51 μM (P-glycoprotein)[1]
In Vitro

Laniquidar potently inhibits purified P-glycoprotein with an IC50 of 0.51 μM, acts primarily as an inhibitor rather than a substrate, and has higher P-gp binding affinity than verapamil[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Laniquidar Related Antibodies
In Vivo

11C]laniquidar (20-100 MBq; i.v.; single dose) shows low cerebral uptake in healthy Wistar rats, which is significantly increased by cyclosporine A pretreatment but unaffected by valspodar, and exhibits relatively low in vivo plasma metabolism[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats[1]
Dosage: 20 MBq; 100 MBq (metabolic stability)
Administration: i.v.; single dose
Result: Showed relatively high peripheral organ uptake in lung, liver, spleen, and kidney, with 30-minute %ID/g values of 4.49 (lung), 2.10 (liver), 1.08 (kidney), and 0.51 (heart).
Exhibited rapid blood clearance, with %ID/g below 0.11 by 5 minutes post-injection.
Demonstrated low cerebral uptake across all dissected brain regions, with relatively constant %ID/g from 5 to 60 minutes except for the olfactory bulb, which showed steadily increasing uptake.
Increased cerebral uptake significantly with cyclosporine A pretreatment, with cyclosporine A/normal ratios of 7.87 (cerebellum), 5.80 (hippocampus), 8.94 (cortex), and 7.89 (striatum) at 30 minutes post-injection.
Showed no significant effect on cerebral uptake with valspodar pretreatment compared to controls.
Had 68.0% of plasma radioactivity corresponding to parent [11C]laniquidar, with 31.5% as polar radioactive metabolites at 30 minutes post-injection.
Clinical Trial
Molecular Weight

584.71

Formula

C37H36N4O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=C2/C(C3=C(CCN21)C=CC=C3)=C4CCN(CC\4)CCC5=CC=C(C=C5)OCC6=NC7=C(C=C6)C=CC=C7)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (17.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7102 mL 8.5512 mL 17.1025 mL
5 mM 0.3420 mL 1.7102 mL 3.4205 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7102 mL 8.5512 mL 17.1025 mL 42.7562 mL
5 mM 0.3420 mL 1.7102 mL 3.4205 mL 8.5512 mL
10 mM 0.1710 mL 0.8551 mL 1.7102 mL 4.2756 mL
15 mM 0.1140 mL 0.5701 mL 1.1402 mL 2.8504 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Laniquidar Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Laniquidar197509-46-9P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243valspodarmultidrug resistance transporterR102207epilepsyWistar ratscyclosporine AInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Laniquidar
Cat. No.:
HY-132189
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (251 KB) Français - FR (251 KB) Deutsch - DE (251 KB) Norwegian - NO (251 KB) Español - ES (251 KB) Swedish - SV (251 KB) Italian - IT (251 KB) Korean - KR (251 KB) Portuguese - PT (251 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.