Leminoprazole
Leminoprazole (NC 1300O3) is an inhibitor for acid pump, H+ K+-ATPase,. Leminoprazole stimulates the secretion and synthesis of gastric mucus, attenuates gastric ulcers. Leminoprazole is orally active.
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- CAS No.: 104340-86-5
- Formule: C19H23N3OS
- Masse moléculaire:341.47
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Leminoprazole inhibits H+,K+-ATPase in rabbit gastric vesicle irreversibly through formation of covalent disulfide bond, with IC50 of 5.3 and 19 μM[1].
Leminoprazole inhibits histamine, carbachol, gastrin and db-cAMP-stimulated acid secretion, with IC50s of 0.4, 0.35, 0.25 and 0.56 μM, respectively[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Donyru rats model[3]
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Dosage:10-90 mg/kg
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Administration:p.o., single dose
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Result:Increased levels of glucosamine, decreased acid secretion.
Chemical Information
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CAS No. 104340-86-5
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Masse moléculaire 341.47
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Formule C19H23N3OS
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SMILES
CC(CN(C1=C(CS(C2=NC3=C(N2)C=CC=C3)=O)C=CC=C1)C)C
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Synonyms
NC 1300O3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Masuda M, et al., [Studies on the inhibitory action of leminoprazole against rabbit gastric H+,K(+)-ATPase]. Nihon Yakurigaku Zasshi. 1994 Oct;104(4):325-35. Japanese. [Content Brief]
[2]. Saito E, et al., Inhibitory effect of leminoprazole on acid secretion in parietal cells isolated from guinea pig gastric mucosa. Jpn J Pharmacol. 1995 May;68(1):19-23. [Content Brief]
[3]. Takahashi S, et al., Mechanism by which orally administered leminoprazole stimulates mucus synthesis in rats. Pharmacology. 1998 Jul;57(1):47-56. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Leminoprazole Related Classifications
HY-105094 Related Classifications
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