LWG-301
Based on 1 publication(s) in Google Scholar
LWG-301 is an allosteric inhibitor of Glutaminase 1 (GLS1) with an IC50 value of 7 nM. LWG-301 significantly block glutamine metabolism, increases intracellular ROS, thus induces apoptosis. LWG-301 exhibits moderate antitumor effects in HCT116 xenograft model.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3038480-88-2
- 分子式: C28H38N8O3S
- 分子量:566.72
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 LWG-301
More
生物活性
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.061 μM
Compound: 41a; LWG301
|
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by MTT assay
|
[PMID: 36525694] |
| HCT-116 | IC50 |
41.47 μM
Compound: 41a; LWG301
|
Antiproliferative activity against human HCT-116 cells in presence of alpha-ketoglutarate
Antiproliferative activity against human HCT-116 cells in presence of alpha-ketoglutarate
|
[PMID: 36525694] |
LWG-301 (compound 41a) inhibits HCT116 cancer cells growth with an IC50 value of 61 nM[1].
LWG-301 has great metabolic stability in human liver microsomes with T1/2=108 min, CL=32 μL/min/mg[1].
LWG-301 (10 μM; 6 h) interacts with GLS1 protein in a dose- and time-dependent manner[1].
LWG-301 (0.03-3 μM; 14 d) inhibits the colony formation of HCT116 cells in a concentration-dependent manner[1].
LWG-301 (0.2 μM, 1 μM, 5 μM; 24 h) blocks the metabolism of glutamine thus results a decrease of glutamate, glutathione, and fumaric acid[1].
LWG-301 (1-10 μM; 24 h) induces ROS production and (0.1-10 μM; 24 h) induces apoptosis in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HCT116 cells
-
Concentration:0.001, 0.01, 0.1, 1, and 10 μM
-
Incubation Time:10, 30, 60, 180, 240 min
-
Result:Showed the interaction with GLS1 in a dose- and time-dependent manner.
-
Cell Line:HCT116 cells
-
Concentration:1, 5, and 10 μM
-
Incubation Time:6 hours
-
Result:Induced ROS production in HCT116 cells.
-
Cell Line:HCT116 cells
-
Concentration:0.1, 0.3, 1, 3, and 10 μM
-
Incubation Time:24 hours
-
Result:Induced apoptosis in HCT116 cells
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:HCT116 tumor-bearing nude mice[1]
-
Dosage:100 mg/kg;
-
Administration:Intraperitoneal injection; once a day for 20 days;
-
Result:Reduced tumor growth, resulting in 38.9% tumor growth inhibition.
Showed little toxicity on main organ.
化学情報
-
CAS 番号 3038480-88-2
-
分子量 566.72
-
分子式 C28H38N8O3S
-
SMILES
CCCCOC1=CC=CC(CC(NC2=NN=C(C=C2)N3CCC(CC3)NC4=NN=C(S4)NC(CCCC)=O)=O)=C1
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Death Dis
Fumarate induces LncRNA-MIR4435-2HG to regulate glutamine metabolism remodeling and promote the development of FH-deficient renal cell carcinoma. [Abstract]2024 Feb 19;15(2):151. PMID: 38374146
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Powered by Bioz