2. Neuronal Signaling
  3. Monoamine Oxidase
  4. MAO-B-IN-20

MAO-B-IN-20 (Compound C14) is a potent MAO-B inhibitor with an IC50 of 0.037 μM. MAO-B-IN-20 displays good metabolic stability and brain-blood barrier permeability. MAO-B-IN-20 can be used for the research of Parkinson's disease.

For research use only. We do not sell to patients.

MAO-B-IN-20 Chemical Structure

MAO-B-IN-20 Chemical Structure

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MAO-B-IN-20 Related Antibodies

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Description

MAO-B-IN-20 (Compound C14) is a potent MAO-B inhibitor with an IC50 of 0.037 μM. MAO-B-IN-20 displays good metabolic stability and brain-blood barrier permeability. MAO-B-IN-20 can be used for the research of Parkinson's disease[1].

IC50 & Target[1]

MAO-B

0.037 μM (IC50)

MAO-A

>10 μM (IC50)

In Vitro

MAO-B-IN-20 (Compound C14) can well bind into the active site of MAO-B and shares a similar binding mode with Safinamide (HY-70057)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MAO-B-IN-20 Related Antibodies
In Vivo

MAO-B-IN-20 (Compound C14; 5 mg/kg; i.v.) is rapidly absorbed and crossed the blood-brain barrier within 15 min, reaching the Cmax in 60 min in both plasma and brain. MAO-B-IN-20 exhibits an adequate brain to plasma ratio of 16.20 and high concentration in brain (8753 ng/g) at 60 min[1].
MAO-B-IN-20 (0.08-1.28 mg/kg; i.p.; once) prominently inhibits the MAO-B activity in a dose-dependent manner in the mouse brain[1].
MAO-B-IN-20 (0.3-3 mg/kg; i.p.; once) exhibits a potential efficacy for dopamine deficits in the MPTP (HY-15608)-induced mouse model and significantly increased dopamine concentration in the striatum[1].
Pharmacokinetic profile of MAO-B-IN-20 (Compound C14) in SD ratsa[1]

Compound Route Dose (mg/kg) Cmax (ng/mL) AUCt (ng•h/mL) T1/2 (h) Vss (L/kg) CL (mL/min/kg) F (%)
MAO-B-IN-20 (Compound C14) iv 1 273 305 0.74 3.33 54.2 /
ig 5 436 2280 4.22 / / 149.5

aFasted male SD rats. Dosing volumes: 5 mL/kg for ig and 1 mL/kg for iv. Cmax: Maximum Concentration, AUCt: Area under the plasma concentration-time curve from time 0 to last time of quantifiable concentration; T1/2: Elimination half time, Vss: Steady-state distribution volume, CL: plasma clearance, F: bioavailability.
Pharmacokinetic profile of MAO-B-IN-20 (Compound C14) in ICR micea[1]
Compound Route Dose (mg/kg) Cmax (ng/mL) AUCt (ng•h/mL) T1/2 (h) Vss (L/kg) CL (mL/min/kg) F (%)
MAO-B-IN-20 (Compound C14) iv 2 900 2680 3.37 2.72 11 /
ig 5 913 7950 3.80 / / 104.8

aFasted male ICR mice. Dosing volumes: 5 mL/kg for ig and 2 mL/kg for iv. Cmax: Maximum Concentration, AUCt: Area under the plasma concentration-time curve from time 0 to last time of quantifiable concentration; T1/2: Elimination half time, Vss: Steady-state distribution volume, CL: plasma clearance, F: bioavailability.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced acute mouse model of PD[1]
Dosage: 0.3, 1.0, 3.0 mg/kg
Administration: Intraperitoneal injection, 30 min before MPTP (20 mg/kg, ip) injection
Result: Dopamine concentration in the striatum of mice significantly increased compared with the MPTP-alone-injected group.
Animal Model: SD rats and ICR mice[1]
Dosage: 1, 2 and 5 mg/kg
Administration: IV and IG (Pharmacokinetic Analysis)
Result: Showed good pharmacokinetic profiles.
Molecular Weight

356.37

Formula

C20H18F2N2O2
SMILES

NC([C@@H]1C[C@@H](CN1CC2=CC3=C(OC(C4=CC=C(C=C4)F)=C3)C=C2)F)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MAO-B-IN-20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MAO-B-IN-20Monoamine OxidaseMAOParkinson's diseaseSafinamideMPTPdopamineInhibitorinhibitorinhibit

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