1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. nAChR
  3. Mivacurium dichloride

Mivacurium dichloride 

Cat. No.: HY-B1700A
Handling Instructions

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell.

For research use only. We do not sell to patients.

Mivacurium dichloride Chemical Structure

Mivacurium dichloride Chemical Structure

CAS No. : 106861-44-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 113 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 145 In-stock
Estimated Time of Arrival: December 31
50 mg USD 230 In-stock
Estimated Time of Arrival: December 31
100 mg USD 350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Mivacurium dichloride is a benzylisoquinoline derivative and is a short-acting non-depolarizing neuromuscular blocking agent and skeletal muscle relaxant. Mivacurium dichloride couples with the nAChR to reduce or inhibit the depolarizing effect of acetylcholine on the terminal disc of the muscle cell[1][2][3].

In Vitro

Mivacurium induces LAD2 cell degranulation in a dose-dependent manner. Mivacurium stimulates intracellular Ca2+ influx in MRGPRX2-HEK293 cells but not in NC-HEK293 cells. Mivacurium induces the release of only low levels of mediators in LAD2 cells transfected with MRGPRX2-targeted small interfering siRNA[1].

In Vivo

Mivacurium causes pseudo-allergic reactions in C57 wild-type mice by inducing mast cells to release histamine and a decrease in body temperature[1].
Mivacurium is rapidly hydrolyzed in the plasma and has a short duration of action (< 10 min). Mivacurium has many advantages, such as a rapid effect, nonneurological toxicity and a lack of heart rate alteration[1].

Molecular Weight

1100.17

Formula

C₅₈H₈₀Cl₂N₂O₁₄

CAS No.

106861-44-3

SMILES

O=C(OCCC[N+]1(C)[[email protected]](CC2=CC(OC)=C(OC)C(OC)=C2)C3=C(C=C(OC)C(OC)=C3)CC1)CC/C=C/CCC(OCCC[N+]4(C)[[email protected]](CC5=CC(OC)=C(OC)C(OC)=C5)C6=C(C=C(OC)C(OC)=C6)CC4)=O.[Cl-].[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (227.24 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9090 mL 4.5448 mL 9.0895 mL
5 mM 0.1818 mL 0.9090 mL 1.8179 mL
10 mM 0.0909 mL 0.4545 mL 0.9090 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

Mivacurium dichloridenAChRNicotinic acetylcholine receptorsShort-durationnon-depolarizingbenzylisoquinolinesteroidalneuromuscularskeletalmusclerelaxantInhibitorinhibitorinhibit

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Mivacurium dichloride
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