Ffar4 - free fatty acid receptor 4 Gene

Also Known as Ffa4; GT01; Pgr4; Gpr120; Gpr129; O3far1; KPG_013

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107221

Summary

Enables G protein-coupled receptor activity; fatty acid binding activity; and Taste Receptor activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cell communication; and positive regulation of cell differentiation. Acts upstream of or within G protein-coupled receptor signaling pathway and hormone secretion. Located in cilium; endocytic vesicle; and plasma membrane. Is expressed in brown fat; intestine; and liver. Human ortholog(s) of this gene implicated in obesity. Orthologous to human FFAR4 (Free Fatty Acid Receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Ffar4 Products (1)

mRNA Protein Name
NM_181748.2 NP_861413.1 free fatty acid receptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
15619630 MGI
enables fatty acid binding IDA
IDA: Inferred from direct assay
15619630 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20813258 MGI
enables taste receptor activity IMP
IMP: Inferred from mutant phenotype
20573884 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
15619630 MGI
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
31761534 MGI
involved in brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
27853148 MGI
involved in fat cell differentiation IMP
IMP: Inferred from mutant phenotype
22343897 MGI
involved in ghrelin secretion IMP
IMP: Inferred from mutant phenotype
24222669 MGI
acts upstream of or within hormone secretion IDA
IDA: Inferred from direct assay
15619630 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15774482 MGI
involved in negative regulation of cytokine production IDA
IDA: Inferred from direct assay
20813258 MGI
acts upstream of or within negative regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
26828067 MGI
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
20813258 MGI
involved in negative regulation of somatostatin secretion IMP
IMP: Inferred from mutant phenotype
24663807 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27852822 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
15774482 MGI
involved in positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
29343498 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
27853148 MGI
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
27852822 MGI
involved in positive regulation of glucagon secretion IMP
IMP: Inferred from mutant phenotype
24742677 MGI
involved in positive regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
26365922 MGI
involved in regulation of D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
20813258 MGI
involved in white fat cell differentiation IDA
IDA: Inferred from direct assay
31761534 MGI
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
31761534 MGI
located in endocytic vesicle IDA
IDA: Inferred from direct assay
15619630 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15619630 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

free fatty acid receptor 4

  • G-protein coupled receptor 120

  • G-protein-coupled receptor GT01

  • omega-3 fatty acid receptor 1

Ffar4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ffar4 Q7TMA4 Arrb2 Mus musculus Q91YI4
Anti Tag CoIP
20813258
Intra
Ffar4 Q7TMA4 Arrb2 Mus musculus Q91YI4
Anti Bait CoIP
20813258
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182404 Anticancer agent 316 / Unkown
HY-185937 FFAR4 agonist-1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ffar4 NCBI NCBI:338557