FFAR4 - free fatty acid receptor 4 Gene

Also Known as GT01; PGR4; BMIQ10; GPR120; GPR129; O3FAR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 338557

About FFAR4

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:93,566,665-93,590,072 (from NCBI)

This gene has 3 transcripts (splice variants), 127 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in colon (RPKM 6.8), fat (RPKM 2.6) and 2 other tissues.

Summary

This gene encodes a G protein-coupled receptor (GPR) which belongs to the rhodopsin family of GPRs. The encoded protein functions as a receptor for free fatty acids, including omega-3, and participates in suppressing anti-inflammatory responses and Insulin sensitizing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

FFAR4 Products (2)

mRNA Protein Name
NM_001195755.2 NP_001182684.1 free fatty acid receptor 4 isoform GPR120-S
NM_181745.4 NP_859529.2 free fatty acid receptor 4 isoform GPR120-L

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables arrestin family protein binding IDA
IDA: Inferred from direct assay
22282525 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22282525 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
23809162 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
27852822 GOA
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
22282525 GOA
involved in white fat cell differentiation IDA
IDA: Inferred from direct assay
31761534 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
31761534 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
22282525 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
22282525 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22282525 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FFAR4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (57 - 337)

  • 0
  • 100
  • 200
  • 300
  • 377 a.a.
Protein Preferred Names Protein Names

free fatty acid receptor 4

  • G-protein coupled receptor 120

Related Diseases

Diseases Alias
Body Mass Index Quantitative Trait Locus 10

  • Obesity

  • BMIQ10

  • Obesity, Susceptibility To
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Diabetes Mellitus

  • Diabetes
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-182404 Anticancer agent 316 / Unkown
HY-185937 FFAR4 agonist-1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FFAR4 VGNC VGNC:28962
Macaca mulatta FFAR4 VGNC VGNC:72532
Rattus norvegicus FFAR4 RGD RGD:1308252
Canis familiaris FFAR4 VGNC VGNC:40832
Mus musculus FFAR4 MGD MGI:2147577
Felis catus FFAR4 VGNC VGNC:62236
Others FFAR4 NCBI