Arrb2 - arrestin, beta 2 Gene

Also Known as Arr3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 216869

Summary

Enables protein kinase B binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of cell communication; and regulation of protein phosphorylation. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway and regulation of protein phosphorylation. Predicted to be located in several cellular components, including basolateral plasma membrane; cytoplasmic vesicle; and postsynaptic density. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ARRB2 (Arrestin beta 2). [provided by Alliance of Genome Resources, Apr 2022]

Arrb2 Products (4)

mRNA Protein Name
NM_001271358.1 NP_001258287.1 beta-arrestin-2 isoform a
NM_001271359.1 NP_001258288.1 beta-arrestin-2 isoform a
NM_001271360.1 NP_001258289.1 beta-arrestin-2 isoform b
NM_145429.5 NP_663404.1 beta-arrestin-2 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18952848 MGI
enables protein kinase B binding IPI
IPI: Inferred from physical interaction
16051150 MGI
Biological Process GO Annotation Evidence References Source
involved in adult walking behavior IMP
IMP: Inferred from mutant phenotype
16051150 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
27886171 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
27886171 MGI
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
16378096 MGI
involved in negative regulation of interleukin-12 production IMP
IMP: Inferred from mutant phenotype
16378096 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
16378096 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24974728 MGI
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
16378096 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
16378096 MGI
involved in positive regulation of cardiac muscle cell differentiation IDA
IDA: Inferred from direct assay
24974728 MGI
involved in positive regulation of gene expression IDA
IDA: Inferred from direct assay
24974728 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
16051150 MGI
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
24974728 MGI
involved in positive regulation of synaptic transmission, dopaminergic IMP
IMP: Inferred from mutant phenotype
16051150 MGI
involved in postsynaptic signal transduction IDA
IDA: Inferred from direct assay
27886171 MGI
involved in postsynaptic signal transduction IMP
IMP: Inferred from mutant phenotype
27886171 MGI
acts upstream of or within regulation of G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10617462 MGI
acts upstream of or within regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
15218143 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: Inferred from genetic interaction
15218143 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27886171 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
27886171 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
11171997 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-arrestin-2

  • arrestin 3

  • beta arr2

Arrb2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Arrb2 Q91YI4 Ffar4 Mus musculus Q7TMA4
Confocal
20813258
Intra
Arrb2 Q91YI4 Card10 Mus musculus P58660
Anti Tag CoIP
18952848
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01029 ARRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20857 Arrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27372 Arrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arrb2 NCBI NCBI:409