Mal-amido-PEG4-NHS ester
Based on 1 Customer Validation
Mal-amido-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
For research use only. We do not sell to patients.
- Purity: 99.24%
- CAS No.: 756525-99-2
- Formula: C22H31N3O11
- Molecular Weight:513.50
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Storage:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 756525-99-2
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Appearance Solid-Liquid Mixture
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Molecular Weight 513.50
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Formula C22H31N3O11
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Color Off-white to light brown
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SMILES
O=C(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (194.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9474 mL | 9.7371 mL | 19.4742 mL | 48.6855 mL |
| 5 mM | 0.3895 mL | 1.9474 mL | 3.8948 mL | 9.7371 mL | |
| 10 mM | 0.1947 mL | 0.9737 mL | 1.9474 mL | 4.8685 mL | |
| 15 mM | 0.1298 mL | 0.6491 mL | 1.2983 mL | 3.2457 mL | |
| 20 mM | 0.0974 mL | 0.4869 mL | 0.9737 mL | 2.4343 mL | |
| 25 mM | 0.0779 mL | 0.3895 mL | 0.7790 mL | 1.9474 mL | |
| 30 mM | 0.0649 mL | 0.3246 mL | 0.6491 mL | 1.6228 mL | |
| 40 mM | 0.0487 mL | 0.2434 mL | 0.4869 mL | 1.2171 mL | |
| 50 mM | 0.0389 mL | 0.1947 mL | 0.3895 mL | 0.9737 mL | |
| 60 mM | 0.0325 mL | 0.1623 mL | 0.3246 mL | 0.8114 mL | |
| 80 mM | 0.0243 mL | 0.1217 mL | 0.2434 mL | 0.6086 mL | |
| 100 mM | 0.0195 mL | 0.0974 mL | 0.1947 mL | 0.4869 mL |
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