OLIG2
Oligodendrocyte Transcription Factor 2
OLIG2 (oligodendrocyte transcription factor) is a basic helix-loop-helix transcription factor. The protein is of 329 amino acids in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family. The other two members are OLIG1 and OLIG3. The expression of OLIG2 is mostly restricted in central nervous system, where it acts as both an anti-neurigenic and a neurigenic factor at different stages of development. OLIG2 is well known for determining motor neuron and oligodendrocyte differentiation, as well as its role in sustaining replication in early development. It is mainly involved in diseases such as brain tumor and Down syndrome.
OLIG2 is highly expressed in glioblastoma, astrocytoma and oligodendrogliomas, and it serves as a diagnostic marker for glial tumors. OLIG2 also plays a critical role in gliomagenesis and tumor phenotype plasticity. Furthermore, OLIG2 expression has been shown to correlate with survival in patients with SHH-MBs[1][2].
OLIG2 is highly expressed in glioblastoma, astrocytoma and oligodendrogliomas, and it serves as a diagnostic marker for glial tumors. OLIG2 also plays a critical role in gliomagenesis and tumor phenotype plasticity. Furthermore, OLIG2 expression has been shown to correlate with survival in patients with SHH-MBs[1][2].
References:
- [1]. Xu Z, et, al. OLIG2 Is a Determinant for the Relapse of MYC-Amplified Medulloblastoma. Clin Cancer Res. 2022 Oct 3;28(19):4278-4291. [Content Brief]
- [2]. Xu R, et, al. OLIG2 Drives Abnormal Neurodevelopmental Phenotypes in Human iPSC-Based Organoid and Chimeric Mouse Models of Down Syndrome. Cell Stem Cell. 2019 Jun 6;24(6):908-926.e8. [Content Brief]
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OLIG2 Related Products (3)
Related Products (3)
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Antibodies (3)
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CT-179
0 ImagesCT-179 is a brain-penetrant and orally active OLIG2 inhibitor with a human IC50 of 1250 nM. CT-179 disrupts OLIG2 dimerization, phosphorylation, and DNA binding, blocking OLIG2-driven transcription. CT-179 induces G2/M phase arrest and increases G0 population. CT-179 induces apoptosis by reducing anti-apoptotic proteins and increasing cleaved caspase-3 and cleaved PARP. CT-179 can be used for the research of subgroup medulloblastoma.
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OLIG2-IN-1
0 ImagesCat. No.: HY-175530Purity: 98.55%OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme.
