ORF 17583
ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.
For research use only. We do not sell to patients.
- CAS No.: 78441-46-0
- Formula: C13H21N5O2S2
- Molecular Weight:343.47
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
All Histamine Receptor Isoforms
More
Biological Activity
ORF 17583 (100-1000 nM; 30 min) exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing[1].
ORF 17583 (1-10 μM; 60 min) significantly inhibits histamine-induced gastric acid secretion at a concentration of 10 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 78441-46-0
-
Molecular Weight 343.47
-
Formula C13H21N5O2S2
-
SMILES
O=S1N=C(C(NCCSCC2=CC=C(CN(C)C)O2)=N1)NC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz