Abnormal Gastric Acid Secretion

Abnormal gastric acid secretion encompasses conditions such as gastric hyperacidity, characterized by increased acid production that typically emerges around the tenth day of life due to maturation of the gastric mucosa, and hypochlorhydria, which reflects irreversible gastric atrophy and marked intestinal metaplasia. While early-stage gastric cancers are strongly linked to H. pylori infection, this association weakens in late-stage cancers, with only about 70% or fewer cases showing active H. pylori infection, suggesting the bacterium may have been eradicated by host defenses—such as mucus production—or may have disappeared prior to cancer development, indicating that other risk factors were already established.

References:

[1]. Gastric Hypoacidity. sciencedirect.

Abnormal Gastric Acid Secretion (5):

Targets:	Environmental Pollutants (2) Histamine Receptor (2) Bacterial (1) Na+/K+ ATPase (1) Biochemical Assay Reagents (1)

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-B2218D

Magnesium hydroxide, 99%(KT)	1309-42-8
Magnesium hydroxide (Magnesium dihydroxide), 99%(KT) is an orally effective antacid. Magnesium hydroxide, 99%(KT) can form a local strongly alkaline microenvironment, reduce ATP production by consuming H⁺, and hydrolyze cellular phospholipids to disrupt the cellular integrity of microorganisms, thus exhibiting antibacterial activity. Magnesium hydroxide, 99%(KT) downregulates the generation of inflammatory macrophages to alleviate inflammatory responses. Magnesium hydroxide, 99%(KT) can be used in research related to acid peptic diseases and chronic wound infections.

HY-W116335A

Dried aluminum hydroxide gel,United States Pharmacopeia (USP) Reference Standard	21645-51-2
Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard is a commonly used antacid with remarkable compound adhesion and release activity. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard can effectively neutralize gastric acid and relieve stomach discomfort. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard is also often used as an adjuvant in vaccines to enhance immune responses. Dried aluminum hydroxide gel, United States Pharmacopeia (USP) Reference Standard can improve the stability and bioavailability of compounds in preparations.

HY-19170

Z-300	128289-57-6
Z-300 is a selective and orally active histamine H2-receptor antagonist. Z-300 inhibits acid secretion and promotes gastric mucus metabolism in the corpus region.

HY-W983968

ATPase-IN-7	816450-73-4	99.86%
ATPase-IN-7 (Example 1) is a H⁺/K⁺-ATPase inhibitor. ATPase-IN-7 is used in the research of gastrointestinal inflammatory diseases and gastric acid-related diseases.

HY-182427

ORF 17583	78441-46-0
ORF 17583 is a Ranitidine (HY-B0693) analogue and H2 receptor antagonist. ORF 17583 exhibits typical reversible competitive antagonism in the guinea pig right atria model, causing a dose-dependent rightward shift of the histamine concentration-response curve without reducing the maximum effect, and its action is fully reversible upon washing. ORF 17583 can be used for research on peptic ulcers and hyperacidity.

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