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Cat. No.: HY-112865

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Octocog alfa

(Synonyms: ADVATE; BAY 81-8973; Kovaltry)

Octocog alfa (ADVATE; BAY 81-8973; Kovaltry) is a standard half-length recombinant coagulation factor FVIII replacement therapy that also functions as a thrombin generation modulator. Octocog alfa regulates thrombin generation-related parameters in vitro and is used in studies related to severe hemophilia A.

For research use only. We do not sell to patients.

CAS No.: 139076-62-3

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Octocog alfa Chemical Structure

CAS No.: 139076-62-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vivo
- Conjugated
- Reconsititution
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vivo

At a single dose of 50 IU/kg, octocog alfa maintains the average FVIII activity level above 40 IU/dL for less than 1 day, above 10 IU/dL for less than 2 days, and causes no significant changes in coagulation biomarker levels before and after infusion^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Chemical Information

CAS No. 139076-62-3
SMILES

[Octocog alfa]
Synonyms

ADVATE; BAY 81-8973; Kovaltry
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Müller J, et al. Comprehensive laboratory assessment of lonoctocog alfa versus octocog alfa in severe haemophilia A. Haemophilia. 2024;30(5):1203-1209. [Content Brief]

[2]. Lissitchkov T, et al. Pharmacokinetics of recombinant factor VIII in adults with severe hemophilia A: fixed-sequence single-dose study of octocog alfa, rurioctocog alfa pegol, and efanesoctocog alfa. Res Pract Thromb Haemost. 2023;7(4):100176. Published 2023 May 13. [Content Brief]

[3]. Klamroth R, et al. Comparative pharmacokinetics of rVIII-SingleChain and octocog alfa (Advate(®) ) in patients with severe haemophilia A. Haemophilia. 2016;22(5):730-738. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vivo
- Conjugated
- Reconsititution
Chemical Information
Purity & Documentation
References

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Octocog alfa

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit

DPBS Buffer (1×)

Cell Counting Kit-8

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Octocog alfa Related Classifications

HY-112865 Related Classifications