139076-62-3
139076-62-3
Chemical Structure
Octocog alfa
Synonym(s): ADVATE; BAY 81-8973; Kovaltry
- CAS No.: 139076-62-3
- Formula:N/A
- Molecular Weight:N/A
SMILES: [Octocog alfa]
Biological Activity: Octocog alfa (ADVATE; BAY 81-8973; Kovaltry) is a standard half-length recombinant coagulation factor FVIII replacement therapy that also functions as a thrombin generation modulator. Octocog alfa regulates thrombin generation-related parameters in vitro and is used in studies related to severe hemophilia A[1][2][3].
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Octocog alfa | Octocog alfa (ADVATE; BAY 81-8973; Kovaltry) is a standard half-length recombinant coagulation factor FVIII replacement therapy that also functions as a thrombin generation modulator. Octocog alfa regulates thrombin generation-related parameters in vitro and is used in studies related to severe hemophilia A. | |||||||||||||||||||||
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References
- [1]. Müller J, et al. Comprehensive laboratory assessment of lonoctocog alfa versus octocog alfa in severe haemophilia A. Haemophilia. 2024;30(5):1203-1209. [Content Brief]
- [2]. Lissitchkov T, et al. Pharmacokinetics of recombinant factor VIII in adults with severe hemophilia A: fixed-sequence single-dose study of octocog alfa, rurioctocog alfa pegol, and efanesoctocog alfa. Res Pract Thromb Haemost. 2023;7(4):100176. Published 2023 May 13. [Content Brief]
- [3]. Klamroth R, et al. Comparative pharmacokinetics of rVIII-SingleChain and octocog alfa (Advate(®) ) in patients with severe haemophilia A. Haemophilia. 2016;22(5):730-738. [Content Brief]
Keywords
