2. Recombinant Proteins
  3. Cytokines and Growth Factors
  4. Interferon & Receptors
  5. IFN-alpha
  6. IFN-alpha 2b

IFN-alpha 2b

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IFN-alpha 2 (IFNA2; IFN-α2), belongs to the type I interferon family, produced by produced by the plasmacytoid dendritic cells (pDCs) exposure to HIV-1BaL in order to inhibit viral infection[1]. Interferon (IFN) is originally identified as a substance ‘interfering’ with viral replication in vitro. IFN-α/β and related molecules are classified as type I IFNs, as for the other two types of type II IFN (IFN-γ) and type III IFNs (IFN-λ), respectively[2].
IFN-alpha 2 subtype is the only one that is currently licensed to treat infections caused by hepatitis B virus (HBV) and HCV[3]. IFN-alpha 2 shows a Sortilin-dependent trafficking in cells and increases the expression level of interferon-stimulated genes (ISGs) in HIV-infected cells[1][4]. It also exhibits cytotoxic activity against CD8+ T cells and enhances CD4+ T cell depletion[3].
Among the IFN-alpha 2 alleles, IFN-alpha 2b is being the predominant allele while IFNα-2a is less predominant and IFNα-2c only a minor allelic variant[5]. IFN-alpha 2 has a bored application in research of cancer, including some hematological malignancies and solid tumors[6].

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Cat. No. Product Name / Synonyms Species Source
  • HY-P78672
    IFN-alpha 2b/IFNA2 Protein, Human (HEK293, Fc)

    IFN-alpha 2b; IFNA2B; IFN-alpha 2 (alpha 2b); interferon alpha 2b

    		Human HEK293
    IFN-alpha 2a, Human, a cytokine primarily produced by macrophages, displays robust antiviral activities. Its interaction with IFNAR2 is pivotal in mediating essential signaling pathways, contributing to intricate defense mechanisms against viral infections. IFN-alpha 2b/IFNA2 Protein, Human (HEK293, Fc) is the recombinant human-derived IFN-alpha 2b/IFNA2 protein, expressed by HEK293, with C-hFc labeled tag. The total length of IFN-alpha 2b/IFNA2 Protein, Human (HEK293, Fc) is 165 a.a., with molecular weight of 45-55 kDa.
  • HY-P7023
    IFN-alpha 2b/IFNA2 Protein, Human

    rHuIFN-α2b; IFNA; INFA2; IFN-a 2b

    		Human E. coli
    IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. IFN-alpha 2 exerts cytotoxic activity against CD8+ T cells and induces CD4+ T cell depletion. IFN-alpha 2b/IFNA2 Protein, Human contains 165 a.a. (C24-E188), is a protein produced in E. coli with tag free.
  • HY-P701095
    IFN-alpha 2b/IFNA2 Protein, Human (His)

    rHuIFN-α2b; IFNA; IFNA2; IFN-a 2b

    		Human E. coli
    IFN-alpha 2 (IFNA2), belongs to type I interferon family, is a protein secreted by cells infected by a virus and acting on other cells to inhibit viral infection. IFN-alpha 2 exerts cytotoxic activity against CD8+ T cells and induces CD4+ T cell depletion. IFN-alpha 2b/IFNA2 Protein, Human contains 165 a.a., is produced in E. coli with N-6*His tagged.
Cat. No. Product Name Effect Purity