1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interferon & Receptors
  4. IFN-lambda
  5. IFN-lambda 2/IL-28A

IFN-lambda 2 (IL-28A) is a member of the Type-III interferon family. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities[1]. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNλ receptor 1 (IFNLR1) and IL-10 receptor subunit-β (IL-10RB). When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1 (intracellular domain, Tyr406 and Tyr343, Tyr517), and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 (p48) form a trimeric transcription factor complex (ISGF3). The formed ISGF3 complexes then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs) such as IRF7, MX1, and OAS1[2]. Human IFN-lambda 2 shares 65.1% common aa identity with mouse.

Cat. No. Product Name / Synonyms Species Source
  • HY-P72553
    IFN-lambda 2/IL-28A Protein, Human (HEK293, His)

    Interferon lambda-2; IFN-lambda-2; IL-28A; IFNL2; IL28A; ZCYTO20

    Human HEK293
    IFN-lambda 2 (IL-28A) is a member of the Type-III interferon family. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3). The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs). IFN-lambda 2/IL-28A Protein, Human (HEK293, His) is a recombinant human IFN-lambda 2 (V26-V200) with C-terminal 6*His tag, which is expressed in HEK293.
  • HY-P700119AF
    Animal-Free IFN-lambda 2/IL-28A Protein, Human (His)

    Interferon lambda-2; IFN-lambda-2; IL-28A; IFNL2; IL28A; ZCYTO20

    Human E. coli
    IFN-lambda 2/IL-28A protein is a multifunctional cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a key role in antiviral host defense, particularly within epithelial tissues. Animal-Free IFN-lambda 2/IL-28A Protein, Human (His) is the recombinant human-derived animal-FreeIFN-lambda 2/IL-28A protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IFN-lambda 2/IL-28A Protein, Human (His) is 174 a.a., with molecular weight of ~20.60 kDa.
  • HY-P7991
    IFN-lambda 2/IL-28A Protein, Mouse (HEK293, His, solution)

    Interferon-λ2, IFN-λ2, IL-28A

    Mouse HEK293
    IFN-lambda 2/IL-28A Protein, Mouse (HEK 293, His), a type III interferon, is a member of IL-10-interferon family. IFN-lambda 2/IL-28A Protein shows anti-viral, anti-tumor and immune stimulatory properties.
  • HY-P700203AF
    Animal-Free IFN-lambda 2/IL-28A Protein, Mouse (His)

    Interferon-λ2; IFN-λ2; IL-28A

    Mouse E. coli
  • HY-P7991A
    IFN-lambda 2/IL-28A Protein, Mouse (HEK293, N-His)

    Interferon-λ2, IFN-λ2, IL-28A

    Mouse HEK293
    IFN-lambda 2/IL-28A protein is a cytokine with antiviral, antitumor, and immunomodulatory activities. It plays a key role in the antiviral defense of epithelial tissues by binding to IL10RB and IFNLR1 receptor complexes, activating the JAK/STAT signaling pathway. IFN-lambda 2/IL-28A Protein, Mouse (HEK293, N-His) is the recombinant mouse-derived IFN-lambda 2/IL-28A protein, expressed by HEK293 , with N-6*His labeled tag. The total length of IFN-lambda 2/IL-28A Protein, Mouse (HEK293, N-His) is 174 a.a., with molecular weight of ~27 kDa.
  • HY-P77005
    IFN-lambda 2/IL-28A Protein, Human (P.pastoris, His)

    Interferon lambda-2; IFN-lambda-2; IL-28A; IFNL2; IL28A; ZCYTO20

    Human P. pastoris
    IFN-lambda 2 (IL-28A) is a member of the Type-III interferon family. IFN-lambda 2 has antiviral antitumour and immunomodulatory activities. IFN-lambda 2 signals through a heterodimeric receptor complex comprising IFNLR1 and IL-10RB. When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to tyrosine phosphorylation of the IFN-λR1 and activation of STAT1 and STAT2. Activated STAT1 and STAT2 together with IRF-9 form a trimeric transcription factor complex (ISGF3). The formed ISGF3 then translocate to the nucleus and promotes the production of IFN-stimulated genes (ISGs). IFN-lambda 2/IL-28A Protein, Human (P.pastoris, His) is a recombinant human IFN-lambda 2 (V26-V200) with C-terminal His tag, which is expressed in P.pastoris.
Cat. No. Product Name Effect Purity