Pyrazolo[4,3-d]pyrimidines as new generation of cyclin-dependent kinase inhibitors

  • Bioorg Med Chem Lett. 2003 Sep 15;13(18):2989-92. doi: 10.1016/s0960-894x(03)00631-0.
Daniela Moravcová  1 ,  Vladimír Krystof ,  Libor Havlícek ,  Jirí Moravec ,  René Lenobel ,  Miroslav Strnad
Affiliations
  • 1. Isotope Laboratory, Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Vídenská 1083, 14220 Prague 4, Czech Republic.
PMID: 12941318 DOI: 10.1016/s0960-894x(03)00631-0
Abstract

A search among analogues of anti-CDK purines led to the identification of substituted pyrazolo[4,3-d]pyrimidines as novel inhibitors of CDK1/cyclin B. Some of these derivatives also show antiproliferative activity on Cancer cell line K-562, thus may find an application as Anticancer agents.