Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

  • Chem Sci. 2019 Jul 30;10(36):8348-8353. doi: 10.1039/c9sc03504d.
Ruiping Zhang  1  2 ,  Yuling Xu  1 ,  Yi Zhang  1 ,  Hyeong Seok Kim  3 ,  Amit Sharma  3 ,  Jing Gao  4 ,  Guangfu Yang  1 ,  Jong Seung Kim  3 ,  Yao Sun  1
Affiliations
  • 1. Key Laboratory of Pesticides and Chemical Biology , Ministry of Education , International Joint Research Center for Intelligent Biosensor Technology and Health , Center of Chemical Biology , College of Chemistry , Central China Normal University , Wuhan 430079 , China . Email: [email protected].
  • 2. Affiliated Da Yi Hospital of Shanxi Medical University , Taiyuan 020001 , China.
  • 3. Department of Chemistry , Korea University , Seoul 02841 , Korea.
  • 4. Jiangsu Key Laboratory of Medical Optics , Suzhou Institute of Biomedical Engineering and Technology , Chinese Academy of Sciences , Suzhou215163 , China.
PMID: 31803412 DOI: 10.1039/c9sc03504d
Abstract

Small-molecule based multifunctional probes play significant roles in biomedical science and possess high clinical translational ability. However, the preparation of these promising probes without complicated synthetic procedures remains a challenging task. Herein, we rationally designed a high-performance DD-A-DD scaffold molecular dye (SYL) with an intrinsic multifunctional ability and then incorporated it into DSPE-mPEG5000 to facilely construct biocompatible NIR-II fluorescent and photoacoustic (PA) dual-modal theranostic nanoprobes (SYL NPs) (∼120 nm). In vivo studies confirmed that SYL NPs exhibited bright NIR-II fluorescence and PA signals in the tumor region with a promising signal to background ratio (S/B). Meanwhile, SYL NPs demonstrated significantly inhibited tumor growth under laser irradiation with no noticeable side effects. These promising results highlighted SYL NPs as a potential theranostic platform for Cancer diagnosis (NIR-II region) and therapy.

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