Engineering micro oxygen factories to slow tumour progression via hyperoxic microenvironments

  • Nat Commun. 2022 Aug 2;13(1):4495. doi: 10.1038/s41467-022-32066-w.
Weili Wang   #  1 ,  Huizhen Zheng   #  1 ,  Jun Jiang  1 ,  Zhi Li  2 ,  Dongpeng Jiang  3 ,  Xiangru Shi  3 ,  Hui Wang  1 ,  Jie Jiang  1 ,  Qianqian Xie  1 ,  Meng Gao  1 ,  Jianhong Chu  3 ,  Xiaoming Cai  4 ,  Tian Xia  5 ,  Ruibin Li  6
Affiliations
  • 1. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 2. Department of Interventional Radiology, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou, Jiangsu, 215001, China.
  • 3. Institute of Blood and Marrow Transplantation, National Clinical Research Center for Hematologic Diseases, Soochow University, Suzhou, China.
  • 4. School of Public Health, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China.
  • 5. Division of NanoMedicine, Department of Medicine, California Nanosystems Institute, University of California, Los Angeles, CA, 90095, USA.
  • 6. State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou, Jiangsu, 215123, China. [email protected].
  • # Contributed equally.
PMID: 35918337 DOI: 10.1038/s41467-022-32066-w
Abstract

While hypoxia promotes carcinogenesis, tumour aggressiveness, metastasis, and resistance to oncological treatments, the impacts of hyperoxia on tumours are rarely explored because providing a long-lasting oxygen supply in vivo is a major challenge. Herein, we construct micro oxygen factories, namely, photosynthesis microcapsules (PMCs), by encapsulation of acquired cyanobacteria and upconversion nanoparticles in alginate microcapsules. This system enables a long-lasting oxygen supply through the conversion of external radiation into red-wavelength emissions for photosynthesis in cyanobacteria. PMC treatment suppresses the NF-kB pathway, HIF-1α production and Cancer cell proliferation. Hyperoxic microenvironment created by an in vivo PMC implant inhibits hepatocarcinoma growth and metastasis and has synergistic effects together with anti-PD-1 in breast Cancer. The engineering oxygen factories offer potential for tumour biology studies in hyperoxic microenvironments and inspire the exploration of oncological treatments.

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