Gold nanoparticles-supported iron oxide particles endows bone scaffolds with anti-tumor function

  • Free Radic Res. 2025 Feb 18:1-14. doi: 10.1080/10715762.2025.2466246.
Tiantian He  1 ,  Wenjing Yang  1 ,  Youwen Yang  1 ,  Shuping Peng  2  3 ,  Cijun Shuai  1  4
Affiliations
  • 1. Jiangxi Province Key Laboratory of Additive Manufacturing of Implantable Medical Device, Jiangxi University of Science and Technology, Nanchang, China.
  • 2. The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Xiangya Hospital, Central South University, Changsha, China.
  • 3. NHC Key Laboratory of Carcinogenesis, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, China.
  • 4. State Key Laboratory of Precision Manufacturing for Extreme Service Performance, College of Mechanical and Electrical Engineering, Central South University, Changsha, China.
PMID: 39936845 DOI: 10.1080/10715762.2025.2466246
Abstract

Iron oxide (Fe-O) has anti-tumor properties, due to its ability of catalyzing hydrogen peroxide (H2O2) of tumor cells to generate Reactive Oxygen Species (ROS) and then cause Ferroptosis. Its anti-tumor performance is restricted due to insufficient H2O2 in tumor cells. A nanomedicine, Au nanoparticles (NPs) grown on Fe-O, was integrated into poly-l-lactide (PLLA) scaffolds. Results indicated that Au NPs could consume glucose of tumor cells to produce H2O2, which supplemented reaction substrate. PLLA/Au@Fe-O scaffold showed enhanced anti-tumor activities against MG63, including increased mortality, decreased migration and colony formation. PLLA/Au@Fe-O scaffold promoted Ferroptosis in MG63, including up-regulation of COX-2 protein, down-regulation of FTH1 protein and GPX4 protein. PLLA/Au@Fe-O scaffold also promoted Autophagy in MG63, including down-regulation of p62 protein, and up-regulation of LC3BII/I. Mechanistically, PLLA/Au@Fe-O scaffold possessed enhanced anti-tumor activities through promoting Ferroptosis and Autophagy.

Keywords
Biological scaffold; anti-tumor; selective laser sintering.
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