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SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA.

For research use only. We do not sell to patients.

SBI-993 Chemical Structure

SBI-993 Chemical Structure

CAS No. : 2073059-82-0

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Based on 1 publication(s) in Google Scholar

SBI-993 Related Antibodies

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Description

SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA[1].

In Vitro

SBI-993 reduces thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) expression in human myotubes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SBI-993 Related Antibodies
In Vivo

SBI-993 (50 mg/kg; s.c.; daily; for 7 days) treatment reduces the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver. SBI-993 also reduces Txnip and Arrdc4 expression. And ccupation of both ChREBP and MondoA on the Txnip and pyruvate kinase (Pklr) gene promoters is reduced in liver by SBI-993[1].
SBI-993 improves insulin signaling in both muscle and liver following an acute insulin challenge[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice are fed a 60% high-fat diet (HFD)[1]
Dosage: 50 mg/kg
Administration: s.c.; daily; for 7 days
Result: Reduced the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver.
Molecular Weight

452.53

Formula

C23H24N4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(C2=CC=C(OC)C=C2)=CS1)C3=CC=C(NCC(N4CCOCC4)=O)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (220.98 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2098 mL 11.0490 mL 22.0980 mL
5 mM 0.4420 mL 2.2098 mL 4.4196 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.67%

COA (246 KB) HNMR (281 KB) LCMS (271 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2098 mL 11.0490 mL 22.0980 mL 55.2450 mL
5 mM 0.4420 mL 2.2098 mL 4.4196 mL 11.0490 mL
10 mM 0.2210 mL 1.1049 mL 2.2098 mL 5.5245 mL
15 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6830 mL
20 mM 0.1105 mL 0.5524 mL 1.1049 mL 2.7622 mL
25 mM 0.0884 mL 0.4420 mL 0.8839 mL 2.2098 mL
30 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
40 mM 0.0552 mL 0.2762 mL 0.5524 mL 1.3811 mL
50 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1049 mL
60 mM 0.0368 mL 0.1841 mL 0.3683 mL 0.9207 mL
80 mM 0.0276 mL 0.1381 mL 0.2762 mL 0.6906 mL
100 mM 0.0221 mL 0.1105 mL 0.2210 mL 0.5524 mL
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SBI-993 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SBI-9932073059-82-0SBI993SBI 993OthersMondoAinsulinTXNIPARRDC4triacylglyceridePklrChREBPInhibitorinhibitorinhibit

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