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SBI-993 

Cat. No.: HY-122682
Handling Instructions

SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA.

For research use only. We do not sell to patients.

SBI-993 Chemical Structure

SBI-993 Chemical Structure

CAS No. : 2073059-82-0

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Description

SBI-993 is a SBI-477 analog with improved potency and suitable pharmacokinetic properties for in vivo bioavailability. SBI-993 stimulates insulin signaling by deactivating the transcription factor MondoA[1].

In Vitro

SBI-993 reduces thioredoxin-interacting protein (TXNIP) and arrestin domain-containing 4 (ARRDC4) expression in human myotubes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SBI-993 (50 mg/kg; s.c.; daily; for 7 days) treatment reduces the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver. SBI-993 also reduces Txnip and Arrdc4 expression. And ccupation of both ChREBP and MondoA on the Txnip and pyruvate kinase (Pklr) gene promoters is reduced in liver by SBI-993[1].
SBI-993 improves insulin signaling in both muscle and liver following an acute insulin challenge[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice are fed a 60% high-fat diet (HFD)[1]
Dosage: 50 mg/kg
Administration: s.c.; daily; for 7 days
Result: Reduced the expression of triacylglyceride synthesis and lipogenic genes in both muscle and liver.
Molecular Weight

452.53

Formula

C₂₃H₂₄N₄O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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SBI-993
Cat. No.:
HY-122682
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