2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. GABA Receptor
  4. SCH 50911

SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM.

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SCH 50911 Chemical Structure

SCH 50911 Chemical Structure

CAS No. : 733717-87-8

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Based on 1 publication(s) in Google Scholar

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Description

SCH 50911, (+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid, a selective, orally-active and competitive γ-Aminobutyric acid B GABA(B) receptor antagonist, binds to GABA(B) receptor with IC50 of 1.1 μM. SCH 50911 antagonizes GABA(B) autoreceptors, increasing the electrically-stimulated 3H overflow with an IC50 of 3 μM[1].

IC50 & Target[1]

GABA(B)

1.1 μM (IC50)

Molecular Weight

173.21

Formula

C8H15NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)C[C@H]1CNC(C)(C)CO1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 12.5 mg/mL (72.17 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7733 mL 28.8667 mL 57.7334 mL
5 mM 1.1547 mL 5.7733 mL 11.5467 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

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In Vivo Dissolution Calculator
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The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.7733 mL 28.8667 mL 57.7334 mL 144.3335 mL
5 mM 1.1547 mL 5.7733 mL 11.5467 mL 28.8667 mL
10 mM 0.5773 mL 2.8867 mL 5.7733 mL 14.4333 mL
15 mM 0.3849 mL 1.9244 mL 3.8489 mL 9.6222 mL
20 mM 0.2887 mL 1.4433 mL 2.8867 mL 7.2167 mL
25 mM 0.2309 mL 1.1547 mL 2.3093 mL 5.7733 mL
30 mM 0.1924 mL 0.9622 mL 1.9244 mL 4.8111 mL
40 mM 0.1443 mL 0.7217 mL 1.4433 mL 3.6083 mL
50 mM 0.1155 mL 0.5773 mL 1.1547 mL 2.8867 mL
60 mM 0.0962 mL 0.4811 mL 0.9622 mL 2.4056 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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SCH 50911 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH 50911733717-87-8SCH50911SCH-50911GABA ReceptorGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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