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Cat. No.: HY-146418

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Antiviral agent 20

Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC₅₀ of 4.5 µM. Antiviral agent 20 has low cytotoxicity.

For research use only. We do not sell to patients.

CAS No.: 2407570-07-2
Formula: C₃₁H₃₅Cl₂NO₆
Molecular Weight:588.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Antiviral agent 20 Chemical Structure

CAS No.: 2407570-07-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Antiviral agent 20 (Compound 17b) is a selective inhibitor against Zika virus infection with an EC₅₀ of 4.5 µM. Antiviral agent 20 has low cytotoxicity^[1].

IC₅₀ & Target

EC₅₀: 4.5 µM (Zika virus)

Cellular Effect

Cell Line	Type	Value	Description	References
SNB-19	CC₅₀	88.7 μM Compound: 160b	Cytotoxicity against human SNB-19 cells incubated for 24 hrs Cytotoxicity against human SNB-19 cells incubated for 24 hrs	[PMID: 33609889]
SNB-19	CC₅₀	88.7 μM Compound: 17b	Cytotoxicity against human SNB19 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay Cytotoxicity against human SNB19 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay	[PMID: 31838328]
SNB-19	EC₅₀	4.5 μM Compound: 17b	Antiviral activity against Zika virus PRVABC-59 infected in human SNB19 cells assessed as reduction in viral titer incubated for 24 hrs by viral titer assay Antiviral activity against Zika virus PRVABC-59 infected in human SNB19 cells assessed as reduction in viral titer incubated for 24 hrs by viral titer assay	[PMID: 31838328]
Vero	CC₅₀	85 μM Compound: 160b	Cytotoxicity against african green monkey Vero cells incubated for 48 hrs Cytotoxicity against african green monkey Vero cells incubated for 48 hrs	[PMID: 33609889]
Vero	CC₅₀	85 μM Compound: 17b	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 31838328]

Chemical Information

CAS No. 2407570-07-2
Molecular Weight 588.52
Formula C₃₁H₃₅Cl₂NO₆
SMILES

[H][C@]12CCC([C@H]([C@@]1(CC[C@H]([C@]2(COC(C)=O)C)O)C)C/C=C3C(OC[C@H]/3OC4=C(C=C(C5=C4N=CC=C5)Cl)Cl)=O)=C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li F, et al. Design, synthesis and discovery of andrographolide derivatives against Zika virus infection. Eur J Med Chem. 2020 Feb 1;187:111925. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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