CACYBP - calcyclin binding protein Gene

Also Known as SIP; GIG5; PNAS-107; S100A6BP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27101

About CACYBP

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:174,999,435-175,012,027 (from NCBI)

This gene has 9 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in brain (RPKM 20.4), ovary (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CACYBP Products (2)

mRNA Protein Name
NM_001007214.1 NP_001007215.1 calcyclin-binding protein isoform 2
NM_014412.3 NP_055227.1 calcyclin-binding protein isoform 1

CACYBP Protein Structure

Siah-Interact_N

Siah-Interact_N: Siah interacting protein, N terminal (4 - 75)

CS

CS: CS domain (77 - 156)

SGS

SGS: SGS domain (161 - 218)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

calcyclin-binding protein

  • S100A6-binding protein

CACYBP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CACYBP Q9HB71 S100A6 Homo sapiens P06703
FPS
31837246
Intra
CACYBP Q9HB71 S100A4 Homo sapiens P26447
FPS
31837246
Intra
CACYBP Q9HB71 S100A5 Homo sapiens P33763
FPS
31837246
Cross: Cross-species interaction Intra: Intraspecies interaction

CACYBP Antibodies

Cat. No. Product Name Application Reactivity
HY-P811285 CACYBP Antibody WB, ICC/IF Human, Mouse, Rat
HY-P85071 S100A6BP Antibody (YA4763) WB, IHC-P, ICC/IF, IP, ELISA, IF-Tissue Human, Mouse, Rat

Related Diseases

Diseases Alias
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01817 CACYBP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CACYBP VGNC VGNC:26693
Macaca mulatta CACYBP VGNC VGNC:70678
Mus musculus CACYBP MGD MGI:1270839
Felis catus CACYBP VGNC VGNC:97371
Rattus norvegicus CACYBP RGD RGD:1303146
Canis familiaris CACYBP VGNC VGNC:55735
Others CACYBP NCBI