CACYBP - calcyclin binding protein Gene

Homo sapiens

Also known as SIP; GIG5; PNAS-107; S100A6BP

Gene ID: 27101 | Gene type: protein coding

About CACYBP

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:174,999,435-175,012,027 (from NCBI)

This gene has 9 transcripts (splice variants) and 240 orthologues. Ubiquitous expression in brain (RPKM 20.4), ovary (RPKM 13.4) and 25 other tissues.

Summary

The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CACYBP Products(2)

mRNA	Protein	Name
NM_001007214.1	NP_001007215.1	calcyclin-binding protein isoform 2
NM_014412.3	NP_055227.1	calcyclin-binding protein isoform 1

CACYBP Protein Structure

Siah-Interact_N

SGS

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

calcyclin-binding protein

S100A6-binding protein

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01817	CACYBP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CACYBP	VGNC	VGNC:26693
Macaca mulatta	CACYBP	VGNC	VGNC:70678
Mus musculus	CACYBP	MGD	MGI:1270839
Felis catus	CACYBP	VGNC	VGNC:97371
Rattus norvegicus	CACYBP	RGD	RGD:1303146
Canis familiaris	CACYBP	VGNC	VGNC:55735

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