S100A5 - S100 calcium binding protein A5 Gene

Also Known as S100D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6276

About S100A5

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,537,147-153,543,685 (from NCBI)

This gene has 2 transcripts (splice variants), 351 orthologues and 21 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca2+ affinity 20- to 100-fold higher than the Other S100 proteins studied under identical conditions. This protein also binds Zn2+ and Cu2+, and Cu2+ strongly which impairs the binding of Ca2+. This protein is expressed in very restricted regions of the adult brain. [provided by RefSeq, Jul 2008]

S100A5 Products (4)

mRNA Protein Name
NM_001394232.1 NP_001381161.1 protein S100-A5
NM_001394233.1 NP_001381162.1 protein S100-A5
NM_001394234.1 NP_001381163.1 protein S100-A5
NM_002962.2 NP_002953.2 protein S100-A5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
19536568 GOA
enables copper ion binding IDA
IDA: Inferred from direct assay
19536568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
31837246 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
19536568 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
19536568 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
12118070 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

S100A5 Protein Structure

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 42)

  • 0
  • 92 a.a.
Protein Preferred Names Protein Names

protein S100-A5

S100A5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
S100A5 P33763 CACYBP Homo sapiens Q9HB71
FPS
31837246
Intra
S100A5 P33763 CACYBP Homo sapiens Q9HB71
ITC
31837246
Intra
S100A5 P33763 TRPM4 Homo sapiens Q8TD43
FPS
31837246
Intra
S100A5 P33763 SLC8A1 Homo sapiens P32418
FPS
31837246
Intra
S100A5 P33763 MYH9 Homo sapiens P35579
FPS
31837246
Intra
S100A5 P33763 CAPZA1 Homo sapiens P52907
FPS
31837246
Intra
S100A5 P33763 TP53 Homo sapiens P04637
FPS
31837246
Intra
S100A5 P33763 MDM4 Homo sapiens O15151
FPS
31837246
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Epidermoid Cysts

  • Epidermoid Cyst

  • Sebaceous Cyst

  • Epidermal Inclusion Cyst

  • Epidermal Cyst
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Pulmonary Systemic Sclerosis

  • Lung Disease With Systemic Sclerosis

  • Lung Involvement In Systemic Sclerosis
Psoriasis 7

  • PSORS7

  • Psoriasis 7, Susceptibility To

  • Psoriasis Susceptibility 7

  • Psoriasis

  • Psoriasis Vulgaris

  • Pv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12381 S100A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19525 S100a5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26020 S100a5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus S100A5 MGD MGI:1338915
Felis catus S100A5 VGNC VGNC:64841
Canis familiaris S100A5 VGNC VGNC:45831
Rattus norvegicus S100A5 RGD RGD:1308996
Bos taurus S100A5 VGNC VGNC:34245
Macaca mulatta S100A5 VGNC VGNC:76959
Others S100A5 NCBI