CAPZA1 - capping actin protein of muscle Z-line subunit alpha 1 Gene

Also Known as CAPZ; CAZ1; CAPPA1

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 829

About CAPZA1

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,619,832-112,671,616 (from NCBI)

This gene has 6 transcripts (splice variants), 145 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 69.5), appendix (RPKM 61.9) and 25 other tissues.

Summary

CAPZA1 is a member of the F-actin capping protein alpha subunit family. This gene encodes the alpha subunit of the barbed-end actin binding protein. The protein regulates growth of the actin filament by capping the barbed end of growing actin filaments. [provided by RefSeq, Jul 2008]

CAPZA1 Products (1)

mRNA Protein Name
NM_006135.3 NP_006126.1 F-actin-capping protein subunit alpha-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
22891260 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in cell junction assembly IMP
IMP: Inferred from mutant phenotype
22891260 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of WASH complex IDA
IDA: Inferred from direct assay
19922875 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPZA1 Protein Structure

F-actin_cap_A

F-actin_cap_A: F-actin capping protein alpha subunit (12 - 282)

  • 0
  • 100
  • 200
  • 286 a.a.
Protein Preferred Names Protein Names

F-actin-capping protein subunit alpha-1

  • Cap Z

CAPZA1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CAPZA1 P52907 CAPZB Homo sapiens P47756
Crosslink
30021884
Intra
CAPZA1 P52907 S100B Homo sapiens P04271
FPS
31837246
Intra
CAPZA1 P52907 S100A5 Homo sapiens P33763
FPS
31837246
Intra
CAPZA1 P52907 S100A1 Homo sapiens P23297
FPS
31837246
Intra
CAPZA1 P52907 S100P Homo sapiens P25815
FPS
31837246
Cross: Cross-species interaction Intra: Intraspecies interaction

CAPZA1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P86798 CAPZA1 Antibody (YA6491) WB, ICC/IF, IHC-P Human, Mouse, Rat

関連疾患

Diseases Alias
Patellar Tendinitis

  • Patellar Tendonitis
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS01902 CAPZA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29162 Mov10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Bos taurus CAPZA1 VGNC VGNC:26756
Macaca mulatta CAPZA1 VGNC VGNC:99862
Rattus norvegicus CAPZA1 RGD RGD:1587438
Felis catus CAPZA1 VGNC VGNC:80155
Mus musculus CAPZA1 MGD MGI:106227
Others CAPZA1 NCBI