SLC8A1 - solute carrier family 8 member A1 Gene

Homo sapiens

Also known as NCX1

Gene ID: 6546 | Gene type: protein coding

About SLC8A1

Cytogenetic location: 2p22.1 Genomic coordinates (GRCh38): 2:40,097,270-40,512,435 (from NCBI)

This gene has 19 transcripts (splice variants), 287 orthologues and 7 paralogues. Broad expression in heart (RPKM 35.6), endometrium (RPKM 9.9) and 16 other tissues.

Summary

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

SLC8A1 Products(23)

mRNA	Protein	Name
NM_001112800.4	NP_001106271.1	sodium/calcium exchanger 1 isoform B precursor
NM_001112801.3	NP_001106272.1	sodium/calcium exchanger 1 isoform C precursor
NM_001112802.2	NP_001106273.1	sodium/calcium exchanger 1 isoform D precursor
NM_001252624.2	NP_001239553.1	sodium/calcium exchanger 1 isoform E precursor
NM_001351483.2	NP_001338412.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351484.2	NP_001338413.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351485.2	NP_001338414.1	sodium/calcium exchanger 1 isoform F precursor
NM_001351486.2	NP_001338415.1	sodium/calcium exchanger 1 isoform G precursor
NM_001351487.2	NP_001338416.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351488.2	NP_001338417.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351489.2	NP_001338418.1	sodium/calcium exchanger 1 isoform H precursor
NM_001351490.2	NP_001338419.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351491.2	NP_001338420.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351492.2	NP_001338421.1	sodium/calcium exchanger 1 isoform I precursor
NM_001351493.2	NP_001338422.1	sodium/calcium exchanger 1 isoform E precursor
NM_001351494.2	NP_001338423.1	sodium/calcium exchanger 1 isoform D precursor
NM_001372263.2	NP_001359192.1	sodium/calcium exchanger 1 isoform A precursor
NM_001394103.1	NP_001381032.1	sodium/calcium exchanger 1 isoform A precursor
NM_001394104.1	NP_001381033.1	sodium/calcium exchanger 1 isoform B precursor
NM_001394105.1	NP_001381034.1	sodium/calcium exchanger 1 isoform H precursor
NM_001394106.1	NP_001381035.1	sodium/calcium exchanger 1 isoform D precursor
NM_001394107.1	NP_001381036.1	sodium/calcium exchanger 1 isoform D precursor
NM_021097.5	NP_066920.1	sodium/calcium exchanger 1 isoform A precursor

SLC8A1 Protein Structure

Na_Ca_ex

Calx-beta

Na_Ca_ex

0
200
400
600
800
973 a.a.

Protein Preferred Names

Protein Names

sodium/calcium exchanger 1

Na(+)/Ca(2+)-exchange protein 1

Related Diseases

Diseases

Alias

Megacolon

Dilatation Of Colon

Penile Cancer

Penis Carcinoma	Carcinoma Of Penis
Penile Neoplasm	Penile Carcinoma
Penile Neoplasms	Malignant Neoplasm Of Penis
Ca Penis	Malignant Neoplasm Of Body Of Penis
Malignant Penile Tumor	Penile Ca

Arrhythmogenic Right Ventricular Cardiomyopathy

Arrhythmogenic Right Ventricular Dysplasia	Arvc
Arvd	Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy
Arvc Cardiomyopathy	Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia
Arvd/C	Right Ventricular Dysplasia, Arrhythmogenic
Ventricular Dysplasia, Right, Arrhythmogenic	Cardiomyopathy, Ventricular, Right, Arrhythmogenic
Dysplasia, Arrhythmogenic Right Ventricular

Ischemia

Acute Coronary Syndrome

Ventricular Tachycardia, Catecholaminergic Polymorphic, 3

Catecholaminergic Polymorphic Ventricular Tachycardia 3	CPVT3
Cvpt3	Tachycardia, Ventricular, Catecholaminergic Polymorphic, Type 3

Penile Benign Neoplasm

Neoplasm Of Penis	Penile Tumor
Cancer Of Penis	Carcinoma Of Penis
Malignant Neoplasm Of Penis, Unspecified	Malignant Neoplasm Of Penis, Part Unspecified
Malignant Tumour Of Penis	Penile Cancer
Primary Malignant Neoplasm Of Penis	Malignant Neoplasm Of Skin Of Penis Nos

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Catecholaminergic Polymorphic Ventricular Tachycardia

Cpvt	Catecholamine-Induced Polymorphic Ventricular Tachycardia
Familial Polymorphic Ventricular Tachycardia	Malignant Paroxysmal Ventricular Tachycardia
Multifocal Ventricular Premature Beats	Stress-Induced Polymorphic Ventricular Tachycardia
Bidirectional Tachycardia Induced By Catecholamine	Double Tachycardia Induced By Catecholamines
Polymorphic Catecholergic Ventricular Tachycardia	Syncopal Paroxysmal Tachycardia
Bidirectional Tachycardia Induced By Catecholamines	Fpvt
Bidirectional Ventricular Tachycardia Induced By Catecholamine	Polymorphic Ventricular Tachycardia Induced By Catecholamines
Ventricular Tachycardia, Catecholaminergic Polymorphic	Ventricular Tachycardia, Catecholaminergic Polymorphic, 1
Familial Ventricular Tachycardia	Multifocal Pvcs
Multifocal Premature Ventricular Beats

Long Qt Syndrome 1

Romano-Ward Syndrome	LQT1
Ward-Romano Syndrome	Rws
Ventricular Fibrillation With Prolonged Qt Interval	Wrs
Long Qt Syndrome 1, Acquired, Susceptibility To	Long Qt Syndrome 1, Acquired
Romano-Ward Long Qt Syndrome	Long Qt Syndrome Type 1
Long Qt Syndrome-1	Acquired Susceptibility To Long Qt Syndrome 1
Qt Syndrome, Long, Type 1

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13337	SLC8A1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS13340	SLC8B1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC8A1	RGD	RGD:3717
Canis familiaris	SLC8A1	VGNC	VGNC:46480
Felis catus	SLC8A1	VGNC	VGNC:81221
Bos taurus	SLC8A1	VGNC	VGNC:34935
Mus musculus	SLC8A1	MGD	MGI:107956
Macaca mulatta	SLC8A1	VGNC	VGNC:77634

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