NCX1 Antibody (YA2331)
(Synonyms: Na+/Ca2+ exchanger; NCX1; SLC8A1)
Based on 1 Customer Validation
NCX1 Antibody (YA2331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCX1.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human, Mouse, Rat
-
Formulation:
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NCX1 Antibody (YA2331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NCX1.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman, Mouse, Rat
-
Observed Molecular WeightObserved band size: 109 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 109 kDa
Entrez Gene: 6546 Human ; 20541 Mouse ; 29715 Rat
SwissProt: P32418 Human ; P70414 Mouse ; Q01728 Rat
OMIM: 182305 Human
A synthesized peptide derived from human NCX1 aa50-100/973.
Endogenous
Affinity Chromatography
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
-
Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
NCX1 mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions[1][2][3].
-
Subcellular Localization
Cell membrane; Multi-pass membrane protein
-
Expression
Tissue_specificity:Detected primarily in heart and at lower levels in brain (PubMed:1374913) . Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung (PubMed:1476165) -
Isoforms & Post-Translational Modification
P32418 has 5 isomers: P32418-1: 108547 Da (predicted); P32418-2: 104689 Da (predicted); P32418-3: 107242 Da (predicted); P32418-4: 107850 Da (predicted); P32418-5: 107938 Da (predicted).
-
SwissProt ID
-
Synonyms
Na+/Ca2+ exchanger; NCX1; SLC8A1
-
Research Field
Signal Transduction
Documentation
Powered by Bioz
