2 Results for "

57-22-7

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "57-22-7" in MCE Product Catalog:

77
Vincristine
Vincristine
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77 Cited Publications
Cat. No.: HY-N0488A
CAS No.: 57-22-7
Synonyms: Leurocristine; NSC-67574; 22-Oxovincaleukoblastine
Category:  

Apocynaceae Alkaloids Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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77
Vincristine sulfate
Vincristine sulfate
0 Images
77 Cited Publications
Cat. No.: HY-N0488
CAS No.: 2068-78-2
Synonyms: Leurocristine sulfate; NSC-67574 sulfate; 22-Oxovincaleukoblastine sulfate
Category:  

Apocynaceae Alkaloids Anti-aging Plants Disease Research Fields Cancer Alkaloid Dimers Catharanthus roseus (L.) G. Don

Target:  

Apoptosis Microtubule/Tubulin Mitosis

Vincristine (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) sulfate is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a Ki of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas .
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