1 Result for "

67-99-2

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "67-99-2" in MCE Product Catalog:

2
Gliotoxin
Gliotoxin
0 Images
2 Cited Publications
Cat. No.: HY-N6727
CAS No.: 67-99-2
Synonyms: Aspergillin
Category:  

Anti-inflammation/Immunoregulatory Disease Research Antibacterial Biological Pesticide Research Other Antibiotics Agricultural Research Infection Microorganisms Antibiotics Disease Research Fields Inflammation/Immunology

Target:  

Apoptosis PKA NF-κB Bacterial Fungal Antibiotic

Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
loading...
    loading...
View All Sizes
Assay Types