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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
AurB
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "AurB" in MCE Product Catalog:
14
14 Publications Verification
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BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC50=1.8 and 1.7 nM, respectively; Ki=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC50 values of 6, 44, 7, 4, 9, and 25 nM, respectively .
3
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LY3295668 (AK-01) is a highly specific and orally active inhibitor of Aurora-A kinase with a Ki values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis. LY3295668 avoids the formation of polyploids related to AurB inhibition. LY3295668 can be used for the study of small cell lung cancer .
2
2 Cited Publications
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ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC50 value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion . ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia . ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage
Cat. No.: HY-13497
CAS No.: 1404437-49-5
STK33-IN-1 (compound 1) is a STK33 inhibitor, with an IC50 of 7 nM .
Cat. No.: HY-W100186
CAS No.: 80047-24-1
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Win 47338 (compound 14) is a control compound of inhibitors of the mitotic kinase monopolar spindle MPS1 and Aurora kinases (AurA/AurB) (Ki>100 μM) .
Cat. No.: HY-RS01271
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Aurkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Aurkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01270
Research Areas:
AURKB Human Pre-designed siRNA Set A contains three designed siRNAs for AURKB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-114258A
CAS No.: 1919888-07-5
Synonyms: AK-01 erbumine
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LY3295668 (AK-01) erbumine is a highly specific and orally active inhibitor of Aurora-A kinase with a Ki values for AurA and AurB of 0.8 nM and 1038 nM respectively. LY3295668 erbumine can effectively inhibit the autophosphorylation of AurA, induce mitotic arrest and apoptosis. LY3295668 erbumine avoids the formation of polyploids related to AurB inhibition. LY3295668 erbumine can be used for the study of small cell lung cancer .
Cat. No.: HY-P704867
Purity: ≥ 70%, as determined by reducing SDS-PAGE.
Synonyms: AURKB; Aurora-1; Prev. STK12; STK-1; AIM-1; AIM1; ARK2; Aurora- And Ipl1-Like Midbody-Associated Protein 1 Homolog (Rat); STK5; Aurora- And Ipl1-Like Midbody-Associated Protein 1 Homolog; PPP1R48; Aurora- And Ipl1-Like Midbody-Associated Protein 1; Aik2;
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Cat. No.: HY-10200R
CAS No.: 1001350-96-4
Research Areas:
BMS-754807 (Standard) is the analytical standard of BMS-754807 (HY-10200). This product is intended for research and analytical applications. BMS-754807 is a potent and reversible IGF-1R/IR inhibitor (IC50=1.8 and 1.7 nM, respectively; Ki=<2 nM for both). BMS-754807 also shows potent activities against Met, RON, TrkA, TrkB, AurA, and AurB with IC50 values of 6, 44, 7, 4, 9, and 25 nM, respectively .
Cat. No.: HY-P703463
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: AURKB; Aurora-1; Prev. STK12; STK-1; AIM-1; AIM1; ARK2; Aurora- And Ipl1-Like Midbody-Associated Protein 1 Homolog (Rat); STK5; Aurora- And Ipl1-Like Midbody-Associated Protein 1 Homolog; PPP1R48; Aurora- And Ipl1-Like Midbody-Associated Protein 1; Aik2;
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
