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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
Azo-PROTAC
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "Azo-PROTAC" in MCE Product Catalog:
Cat. No.: HY-180985
Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .
Cat. No.: HY-180983
Azo-PROTAC-4C-trans is a BCR-ABL PROTAC degrader that can efficiently degrade the BCR-ABL fusion protein and ABL protein. Azo-PROTAC-4C-trans exhibits potent selective anti-proliferative activity against K562 cells. Azo-PROTAC-4C-trans allows real-time, reversible regulation of its activity via UV (to inactivate it) /visible light (to activate it) irradiation. Azo-PROTAC-4C-trans can be used for the study of myeloid leukemia .
Cat. No.: HY-180984
Research Areas:
Trans-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl is a synthetic target E3 ligase ligand-conjugate linker, which can be used to synthesize Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-trans is a BCR-ABL PROTAC degrader with anti-tumor activity .
Cat. No.: HY-180986
Research Areas:
Cis-Lenalidomide-CO-Ph-N2-Ph-O-C4-Cl is a synthetic E3 ligand-connector conjugate that can be used for the synthesis of Azo-PROTAC-4C-cis (HY-180985).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
