3 Results for "

Butein

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Butein" in MCE Product Catalog:

7
7 Cited Publications
Cat. No.: HY-16558
CAS No.: 487-52-5
Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone
Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60 c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).
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Cat. No.: HY-16558R
CAS No.: 487-52-5
Synonyms: 2’,3,4,4’-tetrahydroxy Chalcone (Standard)
Butein (Standard) is the analytical standard of Butein. This product is intended for research and analytical applications. Butein is a cAMP-specific PDE inhibitor with an IC50 of 10.4 μM for PDE4 . Butein is a specific protein tyrosine kinase inhibitor with IC50s of 16 and 65 μM for EGFR and p60c-src in HepG2 cells . Butein sensitizes HeLa cells to Cisplatin through AKT and ERK/p38 MAPK pathways by targeting FoxO3a . Butein is a SIRT1 activator (STAC).
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Cat. No.: HY-W082856A
CAS No.: 155048-06-9
Target:  

BCRP

Research Areas:  

Cancer

Butein tetramethyl ether (Compound 20) is a potent and selective breast cancer resistance protein/ATP-binding cassette subfamily G member 2 (BCRP/ABCG2) inhibitor. Butein tetramethyl ether has inhibitory potencies against MCF-7 MX and MDCK BCRP cells with IC50 values of 2.2 and 1.03 μM, respectively. Butein tetramethyl ether is promising for research of cancers .
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