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CRKL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (4) Aurora Kinase (1) Bcr-Abl (4) c-Myc (1) Histone Methyltransferase (1) P-glycoprotein (2) PERK (2) PROTACs (1) Raf (1) Small Interfering RNA (siRNA) (3) STAT (1)
By Research Areas:	Cancer (5)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-125090

PHA-680626	Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis	Cancer
PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells .

HY-RS25806

Crkl Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Crkl Rat Pre-designed siRNA Set A contains three designed siRNAs for Crkl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Crkl Rat Pre-designed siRNA Set A Crkl Rat Pre-designed siRNA Set A

HY-RS19315

Crkl Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Crkl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crkl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Crkl Mouse Pre-designed siRNA Set A Crkl Mouse Pre-designed siRNA Set A

HY-RS03185

CRKL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CRKL Human Pre-designed siRNA Set A contains three designed siRNAs for CRKL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CRKL Human Pre-designed siRNA Set A CRKL Human Pre-designed siRNA Set A

HY-164469

CHMFL-48	Bcr-Abl Apoptosis STAT	Cancer
CHMFL-48 is an orally active BCR-ABL kinase inhibitor targeting both wild-type (wt) and various imatinib-resistant mutants. The IC₅₀ values for CHMFL-48 against ABL wild-type and ABL T315I mutant are 1 nM and 0.8 nM, respectively. CHMFL-48 exerts its effects by blocking the autophosphorylation of BCR-ABL wild-type and mutant forms, which impacts downstream signaling mediators such as STAT5 and *CRKL*, leading to cell cycle arrest and induction of apoptosis. CHMFL-48 holds potential for research into chronic myeloid leukemia (CML) .

HY-178382

BRAFV600E/ABL2-IN-1	Raf Bcr-Abl P-glycoprotein PERK Apoptosis	Cancer
BRAFV600E/ABL2-IN-1 is a BRAF^V600E (IC₅₀ = 0.088 μM)/ABL2 (IC₅₀ = 0.3 μM) dual inhibitor. BRAFV600E/ABL2-IN-1 can diminish P-glycoprotein expression. BRAFV600E/ABL2-IN-1 effectively inhibits *p-CrkL* (Abl2 signaling) and p-ERK1/2 (BRAF^V600E pathway) in A375-R melanoma cells. BRAFV600E/ABL2-IN-1 causes cell cycle arrest. BRAFV600E/ABL2-IN-1 significantly increases the percentage of late apoptotic cells. BRAFV600E/ABL2-IN-1 can be used for the study of melanoma .

HY-180969

SIAIS056	PROTACs Bcr-Abl	Cancer
SIAIS056 is a BCR-ABL PROTAC degrader with a DC₅₀ value of 0.18 nM. SIAIS056 time-dependently inhibits the BCR-ABL signaling pathway, accompanied by decreased phosphorylation of BCR-ABL and the downstream molecules STAT5 and CRKL in K562 cells. SIAIS056 induces the degradation of several clinically relevant resistance-conferring mutations of BCR-ABL. SIAIS056 exhibits anti-proliferative activity and induces substantial tumor regression in K562 xenograft models. SIAIS056 can be used for leukemia research .

HY-181726

BRAFV600E/ABL2-IN-2	PERK P-glycoprotein Apoptosis	Cancer
BRAFV600E/ABL2-IN-2 is a dual BRAFV ^600E and ABL2 kinase inhibitor, with an IC₅₀ of 0.088 μM against human BRAFV ^600E and an IC₅₀ of 0.3 μM against human ABL2. BRAFV600E/ABL2-IN-2 reduces the phosphorylation levels of downstream ERK1/2 and *CrkL* in melanoma cells. BRAFV600E/ABL2-IN-2 decreases the expression of P-glycoprotein (P-glycoprotein) in melanoma cells. BRAFV600E/ABL2-IN-2 induces G1 cell cycle arrest and apoptosis (Apoptosis) in melanoma cells. BRAFV600E/ABL2-IN-2 is applicable to relevant research on melanoma .

Species:	Human (2)
Tag:	His (1) Strep (1) Tag Free (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702048

	CRKL Protein, Human CRKL; Crk-like protein	Human	E. coli
	CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human is the recombinant human-derived CRKL protein, expressed by E. coli , with tag free.

HY-P702049

	CRKL Protein, Human (His, StrepⅡ) CRKL; Crk-like protein	Human	E. coli
	CRKL protein mediates intracellular signal transduction, interacts with tyrosine-phosphorylated EPOR and INPP5D/SHIP1, and plays a role in erythropoietin receptor and phosphoinositide signaling. It also binds to DOCK2 and DOCK5, suggesting regulation of guanine nucleotide exchange factors. CRKL Protein, Human (His, Strep) is the recombinant human-derived CRKL protein, expressed by E. coli , with N-Strep, N-6*His labeled tag.

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Host:	Mouse (1) Rabbit (3)
Reactivity:	Human (4) Rat (2) Mouse (2)
Application:	IHC-P (2) ICC/IF (2) IP (1) WB (4) FC (1) ELISA (2)
Isotype:	IgG,Kappa (1) IgG (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (2)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85109

	CrkL Antibody (YA4801) CRKL; Crk-like protein	WB, FC, ELISA	Human
	CrkL Antibody (YA4801) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CrkL.

HY-P82832

	CrkL Antibody (YA2577) Crk L; Crk like protein; CRKL; Crkol	WB, IHC-P, ICC/IF	Human
	CrkL Antibody (YA2577) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CrkL.

HY-P810591

	*Phospho-CrkL* (Tyr207) Antibody (YA9855)** Crk L; Crk like protein; CRKL; Crkol	WB	Human, Mouse, Rat
	Phospho-CrkL (Tyr207) Antibody (YA9855) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-CrkL (Tyr207).

HY-P87815

	Crk-L Antibody (YA7500)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Crk-L Antibody (YA7500) is a Rabbit-derived and non-conjugated IgG, Kappa monoclonal antibody, targeting to Crk-L.

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Cat. No.	Product Name		Classification

HY-RS25806

Crkl Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Crkl Rat Pre-designed siRNA Set A contains three designed siRNAs for Crkl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS19315

Crkl Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Crkl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Crkl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS03185

CRKL Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
CRKL Human Pre-designed siRNA Set A contains three designed siRNAs for CRKL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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