country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-184100S

Copy Link Print Information

Relcobatinib

(Synonyms: Relcobatinibum)

Relcobatinib (Relcobatinibum) is a ABL1 kinase inhibitor with an IC₅₀ of 12.7 nM against wild-type ABL1 and an IC₅₀ of 43.5 nM against the ABL1^T315I mutant. Relcobatinib inhibits the phosphorylation of CRKL. Relcobatinib exhibits anticancer activity against chronic myeloid leukemia. Relcobatinib can be used in studies related to chronic myeloid leukemia.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 2767305-95-1
화학식: C₁₈H₁₂D₆FN₅O₃
분자량:377.40

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

Relcobatinib Chemical Structure

CAS No.: 2767305-95-1

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

Abl1

12.7 nM (IC₅₀)

Abl1^T315I

43.5 nM (IC₅₀)

All Bcr-Abl Isoforms :

Abl
Bcr-Abl

In Vitro

Relcobatinib (Compound 95) potently inhibits K562 cell proliferation with an IC₅₀ of 47.8 nM and weakly inhibits HL60 cell proliferation with an IC₅₀ of 3550 nM^[1].
Relcobatinib inhibits wild-type ABL1 kinase activity with an IC₅₀ of 12.7 nM and ABL1^T315I mutant kinase activity with an IC₅₀ of 43.5 nM in a cell-free biochemical assay^[1].
Relcobatinib inhibits CRKL phosphorylation in K562 cells with an IC₅₀ of 66.3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

신청

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2767305-95-1
Unlabeled Cas 2767304-26-5
분자량 377.40
화학식 C₁₈H₁₂D₆FN₅O₃
SMILES

CN1C(C2=C(OC([2H])([2H])[2H])N=CN=C2OC([2H])([2H])[2H])=CC3=CC(NC([C@H]4[C@H](C4)F)=O)=NC=C31
Synonyms

Relcobatinibum
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Joseph P. Lyssikatos, et al. 5- and 6-azaindole compounds for inhibition of bcr-abl tyrosine kinases. WO2022076975A1. WIPO (PCT). 2021-10-04.

[2]. International Nonproprietary
Names for Pharmaceutical
Substances (INN). WHO Drug Information, Vol. 39, No. 4, 2025.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

견적 받기 해외재고보유

Amount: USD 0.00

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Relcobatinib

All Bcr-Abl Isoforms

Biological Activity

Chemical Information

순도&문서

References

Calculators

Help & FAQs

Relcobatinib Related Classifications

HY-184100S Related Classifications