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CSN5-IN-3

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112134
    CSN5i-3
    20+ Cited Publications

    		 Deubiquitinase Cancer
    CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM .
    CSN5i-3
  • HY-181795
    CSN5-IN-3

    		PD-1/PD-L1 Bcl-2 Family MDM-2/p53 Caspase Cancer
    CSN5-IN-3 (Compound 30) is a CSN5 inhibitor with an IC50 of 0.58 μM. CSN5-IN-3 inhibits the enzymatic activity of CSN5, leading to increased accumulation of NEDD8-Cul1 and promoting the degradation of PD-L1. CSN5-IN-3 downregulates Bcl-2, and upregulates P53 and Cleaved caspase-3. CSN5-IN-3 exhibits anticancer activity against triple-negative breast cancer .
    CSN5-IN-3
  • HY-112134A
    (R)-CSN5i-3

    		AP-1 Cancer
    (R)-CSN5i-3 is the (R)-enantiomer of CSN5i-3. CSN5i-3 is a potent, selective and orally available inhibitor of CSN5 .
    (R)-CSN5i-3

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