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Results for "

CXCR5

" in MedChemExpress (MCE) Product Catalog:

10

Inhibitors & Agonists

4

Inhibitory Antibodies

1

Recombinant Proteins

3

Antibodies

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-122197
    ML339
    4 Publications Verification

    		 CXCR Apelin Receptor (APJ) Arrestin Cancer
    ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes β-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 μM and 1.4 μM, respectively. ML339 shows weaker activity against the recruitment of β-arrestin in mouse CXCR6 receptors, with an IC50 of 18 μM. ML339 has no inhibitory effect on CXCR5，CXCR4，CXCR6 and apelin receptor (APJ), with IC50 >79 μM. ML339 has the potential to promote the development of prostate cancer research .
    ML339
  • HY-P991567
    VX5

    VX5/5261

    		 CXCR Inflammation/Immunology Cancer
    VX5 (VX5/5261) is a humanized IgG1κ monoclonal antibody inhibitor targeting BCA-1/CXCL13. VX5 significantly inhibits human CXCL13-mediated internalization of CXCR5, blocks both human and mouse CXCL13-dependent B-cells chemotaxis and migration. VX5 can be used to study autoimmune diseases like multiple sclerosis and arthritis, and cancers like gastric lymphomas and colon cancer .
    VX5
  • HY-163480
    PF-06835375

    		CXCR Inflammation/Immunology
    PF-06835375 is a selective, humanized CXCR5-targeting immunoglobulin G1 antibody. PF-06835375 depletes CXCR5-positive B cells, follicular helper T cells and circulating Tfh-like cells. PF-06835375 is applicable to research related to autoimmune diseases .
    PF-06835375
  • HY-RS16995
    Cxcr5 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cxcr5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Cxcr5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cxcr5 Mouse Pre-designed siRNA Set A
    Cxcr5 Mouse Pre-designed siRNA Set A
  • HY-174724
    Human CXCR5 mRNA

    		mRNA Inflammation/Immunology
    Human CXCR5 mRNA encodes the human C-X-C motif chemokine receptor 5 (CXCR5) protein, a multi-pass membrane protein that belongs to the CXC chemokine receptor family. CXCR5 is involved in B-cell migration into B-cell follicles of spleen and Peyer patches.
    Human CXCR5 mRNA
  • HY-RS03409
    CXCR5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CXCR5 Human Pre-designed siRNA Set A contains three designed siRNAs for CXCR5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CXCR5 Human Pre-designed siRNA Set A
    CXCR5 Human Pre-designed siRNA Set A
  • HY-RS23438
    Cxcr5 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Cxcr5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Cxcr5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Cxcr5 Rat Pre-designed siRNA Set A
    Cxcr5 Rat Pre-designed siRNA Set A
  • HY-P991227
    Anti-CD185/CXCR5 Antibody

    BAY-924 antibody

    		 CXCR Cancer
    Anti-CD185/CXCR5 Antibody is an antibody inhibitor, targeting to human CD185/CXCR5.
    Anti-CD185/CXCR5 Antibody
  • HY-P991477
    HFB-100204

    		CXCR Inflammation/Immunology
    HFB-100204 is a human monoclonal antibody (mAb) targeting CXCR5. HFB-100204 reduces CXCR5+ immune cells, including B cells and Tfh cells, in the blood and spleen of hCXCR5 knockout mice. HFB-100204 can be used in autoimmune diseases research .
    HFB-100204
  • HY-182774
    YU241279

    		CXCR Cancer
    YU241279 is an orally active CXCR5 inhibitor. YU241279 inhibits CXCL13-mediated Gαq-dependent calcium influx and Gαi2-dependent cAMP reduction in CXCR5-expressing cells. YU241279 inhibits the proliferation of CXCR5-expressing lymphoma cells. YU241279 reduces tumor burden in the peripheral blood and bone marrow of mice implanted with lymphoma tissues. YU241279 is well tolerated during oral administration in mice, maintains stable plasma drug concentrations, and shows no metabolic changes. YU241279 can be used in the research of angioimmunoblastic T-cell lymphoma and Burkitt B-cell lymphoma .
    YU241279

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